2,2-Dimethyl-propionic acid (Z)-5-{2-[(Z)-6-(2-benzenesulfonylmethyl-4-methoxy-pyridin-3-yl)-hex-3-enyl]-4-methoxy-pyridin-3-yl}-pent-2-enyl ester

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Chemical Name:2,2-Dimethyl-propionic acid (Z)-5-{2-[(Z)-6-(2-benzenesulfonylmethyl-4-methoxy-pyridin-3-yl)-hex-3-enyl]-4-methoxy-pyridin-3-yl}-pent-2-enyl ester
CAS No.:211758-86-0
Molecular Formula:C₃₅H₄₄N₂O₆S
Molecular Weight:620.81
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid (Z)-5-{2-[(Z)-6-(2-benzenesulfonylmethyl-4-methoxy-pyridin-3-yl)-hex-3-enyl]-4-methoxy-pyridin-3-yl}-pent-2-enyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (Z)-5-{2-[(Z)-6-(2-benzenesulfonylmethyl-4-methoxy-pyridin-3-yl)-hex-3-enyl]-4-methoxy-pyridin-3-yl}-pent-2-enyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (Z)-5-{2-[(Z)-6-(2-benzenesulfonylmethyl-4-methoxy-pyridin-3-yl)-hex-3-enyl]-4-methoxy-pyridin-3-yl}-pent-2-enyl ester

There total 12 articles about 2,2-Dimethyl-propionic acid (Z)-5-{2-[(Z)-6-(2-benzenesulfonylmethyl-4-methoxy-pyridin-3-yl)-hex-3-enyl]-4-methoxy-pyridin-3-yl}-pent-2-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 211758-85-9
2,2-Dimethyl-propionic acid (Z)-5-{4-methoxy-2-[(Z)-6-(4-methoxy-2-phenylsulfanylmethyl-pyridin-3-yl)-hex-3-enyl]-pyridin-3-yl}-pent-2-enyl ester

: 211758-86-0
2,2-Dimethyl-propionic acid (Z)-5-{2-[(Z)-6-(2-benzenesulfonylmethyl-4-methoxy-pyridin-3-yl)-hex-3-enyl]-4-methoxy-pyridin-3-yl}-pent-2-enyl ester

Guidance literature:: With ammonium molybdate; dihydrogen peroxide; In ethanol; for 0.2h;
DOI:10.1021/jo9801770

Reference yield:

: 5470-66-6
2-methyl-4-nitropyridine N-oxide

: 211758-86-0
2,2-Dimethyl-propionic acid (Z)-5-{2-[(Z)-6-(2-benzenesulfonylmethyl-4-methoxy-pyridin-3-yl)-hex-3-enyl]-4-methoxy-pyridin-3-yl}-pent-2-enyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 84 percent / PCl₃ / CHCl₃ / 40 h / Ambient temperature

2: 50 percent / NaOH / dimethylsulfoxide / 0.5 h / 15 - 20 °C

3: 83 percent / methanol / Ambient temperature

4: 86 percent / n-BuLi / tetrahydrofuran; hexane / 0.83 h / Ambient temperature

5: 99 percent / Na/Hg, NaH₂PO₄ / methanol / 1 h

6: 1.) n-BuLi / 1.) THF, -78 to -50 deg C, 40 min, 2.) THF, -50 deg C, 5 min, then room temp., 30 min

8: 94 percent / aq. HCl / tetrahydrofuran / 17 h / Ambient temperature

9: 95 percent / Et₃N, 4-dimethylaminopyridine / CH₂Cl₂ / 2 h / Ambient temperature

10: 94 percent / ammonium molybdate, aq. H₂O₂ / ethanol / 0.2 h

With hydrogenchloride; dmap; sodium hydroxide; sodium dihydrogenphosphate; sodium amalgam; n-butyllithium; ammonium molybdate; dihydrogen peroxide; triethylamine; phosphorus trichloride; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; chloroform; dimethyl sulfoxide;
DOI:10.1021/jo9801770

Reference yield:

: 13508-96-8
2-methyl-4-nitro-pyridine

: 211758-86-0
2,2-Dimethyl-propionic acid (Z)-5-{2-[(Z)-6-(2-benzenesulfonylmethyl-4-methoxy-pyridin-3-yl)-hex-3-enyl]-4-methoxy-pyridin-3-yl}-pent-2-enyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 50 percent / NaOH / dimethylsulfoxide / 0.5 h / 15 - 20 °C

2: 83 percent / methanol / Ambient temperature

3: 86 percent / n-BuLi / tetrahydrofuran; hexane / 0.83 h / Ambient temperature

4: 99 percent / Na/Hg, NaH₂PO₄ / methanol / 1 h

5: 1.) n-BuLi / 1.) THF, -78 to -50 deg C, 40 min, 2.) THF, -50 deg C, 5 min, then room temp., 30 min

7: 94 percent / aq. HCl / tetrahydrofuran / 17 h / Ambient temperature

8: 95 percent / Et₃N, 4-dimethylaminopyridine / CH₂Cl₂ / 2 h / Ambient temperature

9: 94 percent / ammonium molybdate, aq. H₂O₂ / ethanol / 0.2 h

With hydrogenchloride; dmap; sodium hydroxide; sodium dihydrogenphosphate; sodium amalgam; n-butyllithium; ammonium molybdate; dihydrogen peroxide; triethylamine; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo9801770