5470-66-6Relevant articles and documents
Large-scale synthesis of a key catalytic reagent for phosphorus protection in building blocks for isopolar phosphonate oligonucleotide preparation
Rejman, Dominik,Erbs, Jiri,Rosenberg, Ivan
, p. 473 - 476 (2000)
A simple procedure for the large-scale synthesis of 4-methoxy-2-pyridinemethanol 1-oxide (5), a key compound in modern triester synthesis of oligonucleotides, employing Buechi R 152 evaporator as a reaction apparatus was elaborated. Two crucial reaction steps, both strongly exothermic, were satisfactorily handled. Our procedure provides a high-purity, light-and heat-stable product in a satisfactory yield.
ANTIBIOTIC COMPOUNDS
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Page/Page column 175, (2018/03/25)
The present invention relates to antibiotic compounds of formula (I), to compositions containing these compounds and to methods of treating bacterial diseases and infections using the compounds. The compounds find application in the treatment of infection with, and diseases caused by, Gram-positive and/or Gram-negative bacteria, and in particular in the treatment of infection with, and diseases caused by, Neisseria gonorrhoeae.
Metal-free methylation of a pyridine N-oxide C-H bond by using peroxides
Li, Gang,Yang, Suling,Lv, Bingjie,Han, Qingqing,Ma, Xingxing,Sun, Kai,Wang, Zhiyong,Zhao, Feng,Lv, Yunhe,Wu, Hankui
supporting information, p. 11184 - 11188 (2015/11/27)
Metal-free methylation of a pyridine N-oxide C-H bond was developed using peroxide as a methyl reagent under neat conditions. Pyridine N-oxide derivatives with various groups (e.g., Cl, NO2, and OCH3) were all suitable substrates, and the desired products were obtained in moderate to excellent yields under standard conditions. Moreover, the methylation can be performed with a good yield on the gram-scale experiment. Tentative mechanistic studies show that the methylation is a classical radical process.
