5-(2,2-dicyano-vinyl)-4-pyrrolidin-1-yl-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

Base Information

• Chemical Name: 5-(2,2-dicyano-vinyl)-4-pyrrolidin-1-yl-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester
• CAS No.: 1028300-74-4
• Molecular Formula: C₂₁H₂₂N₄O₂
• Molecular Weight: 362.431

Synonyms:5-(2,2-dicyano-vinyl)-4-pyrrolidin-1-yl-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

Chemical Property of 5-(2,2-dicyano-vinyl)-4-pyrrolidin-1-yl-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

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Technology Process of 5-(2,2-dicyano-vinyl)-4-pyrrolidin-1-yl-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

There total 2 articles about 5-(2,2-dicyano-vinyl)-4-pyrrolidin-1-yl-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl 4-oxo-1-piperidinecarboxylate (19099-93-5) → 5-(2,2-dicyano-vinyl)-4-pyrrolidin-1-yl-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester (1028300-74-4)

Guidance literature:

Multi-step reaction with 2 steps

1: p-toluenesulfonic acid / benzene / Heating

2: triethylamine / tetrahydrofuran / 1.5 h / -40 - 20 °C

With toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; benzene;

DOI:10.1021/jm0202369

Reference yield:

1-Chloro-2,2-dicyanoethylen (10472-09-0) + benzyl 4-pyrrolidin-1-yl-3,6-dihydro-2H-pyridine-1-carboxylate (91157-41-4) → 5-(2,2-dicyano-vinyl)-4-pyrrolidin-1-yl-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester (1028300-74-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; at -40 - 20 ℃; for 1.5h;

DOI:10.1021/jm0202369

Reference yield:

5-(2,2-dicyano-vinyl)-4-pyrrolidin-1-yl-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester (1028300-74-4) → 2-amino-3-cyano-6-(4-carbobenzyloxy)-5,6,7,8-tetrahydropyrido[4,3-b]pyridine (478273-68-6)

Guidance literature:

With ammonia; In methanol; at 20 ℃;

DOI:10.1021/jm0202369

upstream raw materials:

1-Chloro-2,2-dicyanoethylen

benzyl 4-pyrrolidin-1-yl-3,6-dihydro-2H-pyridine-1-carboxylate

benzyl 4-oxo-1-piperidinecarboxylate

Downstream raw materials:

2-amino-3-cyano-6-(4-carbobenzyloxy)-5,6,7,8-tetrahydropyrido[4,3-b]pyridine

2,4-diamino-7,8-dihydro-5H-1,3,6,9-tetraaza-anthracene-6-carboxylic acid benzyl ester

4-(2,4-diamino-5-deaza-6,7,8,9-tetrahydropyrido[3,4-g]pteridin-7-yl)methylbenzoic acid

2,4-diamino-7-(4-carbomethoxybenzyl)-5-deaza-6,7,8,9-tetrahydropyrido[3,4-g]pteridine

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