2',3'-O-Bis(tert-butyldimethylsilyl)-N²-isobutyroyl-5'-O-(4-methoxytrityl)guanosin

Base Information

• Chemical Name: 2',3'-O-Bis(tert-butyldimethylsilyl)-N²-isobutyroyl-5'-O-(4-methoxytrityl)guanosin
• CAS No.: 79974-69-9
• Molecular Formula: C₄₆H₆₃N₅O₇Si₂
• Molecular Weight: 854.207

Synonyms:2',3'-O-Bis(tert-butyldimethylsilyl)-N²-isobutyroyl-5'-O-(4-methoxytrityl)guanosin

Chemical Property of 2',3'-O-Bis(tert-butyldimethylsilyl)-N²-isobutyroyl-5'-O-(4-methoxytrityl)guanosin

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Technology Process of 2',3'-O-Bis(tert-butyldimethylsilyl)-N²-isobutyroyl-5'-O-(4-methoxytrityl)guanosin

There total 5 articles about 2',3'-O-Bis(tert-butyldimethylsilyl)-N²-isobutyroyl-5'-O-(4-methoxytrityl)guanosin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N2-Isobutyroyl-5'-O-(4-methoxytrityl)guanosin (67607-83-4) + tert-butyldimethylsilyl chloride (18162-48-6) → 2',3'-O-Bis(tert-butyldimethylsilyl)-N2-isobutyroyl-5'-O-(4-methoxytrityl)guanosin (79974-69-9)

Guidance literature:

With 1H-imidazole; In pyridine; N,N-dimethyl-formamide; at 60 ℃; for 48h;

Reference yield: 35.0%

N2-Isobutyroyl-5'-O-(4-methoxytrityl)guanosin (67607-83-4) + tert-butyldimethylsilyl chloride (18162-48-6) → N2-isobutyryl-3'-O-(tert-butyldimethylsilyl)-5'-O-(monomethoxytrityl)guanosine (79983-16-7) + N2-isobutyryl-2'-O-(tert-butyldimethylsilyl)-5'-O-(monomethoxytrityl)guanosine (79536-95-1) + 2',3'-O-Bis(tert-butyldimethylsilyl)-N2-isobutyroyl-5'-O-(4-methoxytrityl)guanosin (79974-69-9)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 0 ℃; for 48h;

Reference yield:

N2-isobutyryl-2'-deoxyguanosine (64350-24-9) → 2',3'-O-Bis(tert-butyldimethylsilyl)-N2-isobutyroyl-5'-O-(4-methoxytrityl)guanosin (79974-69-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / pyridine / 0.67 h / 50 °C

2: 12 percent / imidazol / dimethylformamide / 48 h / 0 °C

With 1H-imidazole; In pyridine; N,N-dimethyl-formamide;

upstream raw materials:

N²-Isobutyroyl-5'-O-(4-methoxytrityl)guanosin

tert-butyldimethylsilyl chloride

N²-isobutyryl-2'-deoxyguanosine

N²-(2-methylpropanoyl)-2',3',5'-tris-O-(2-methylpropanoyl)guanosine

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