(4S,5S)-7-benzyloxy-5-(tert-butyldimethylsilanyloxy)-4-methyl-3-oxoheptanoic acid ethyl ester

Base Information

Chemical Name:(4S,5S)-7-benzyloxy-5-(tert-butyldimethylsilanyloxy)-4-methyl-3-oxoheptanoic acid ethyl ester
CAS No.:375826-97-4
Molecular Formula:C₂₃H₃₈O₅Si
Molecular Weight:422.637
Hs Code.:

Synonyms:(4S,5S)-7-benzyloxy-5-(tert-butyldimethylsilanyloxy)-4-methyl-3-oxoheptanoic acid ethyl ester

Suppliers and Price of (4S,5S)-7-benzyloxy-5-(tert-butyldimethylsilanyloxy)-4-methyl-3-oxoheptanoic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4S,5S)-7-benzyloxy-5-(tert-butyldimethylsilanyloxy)-4-methyl-3-oxoheptanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4S,5S)-7-benzyloxy-5-(tert-butyldimethylsilanyloxy)-4-methyl-3-oxoheptanoic acid ethyl ester

There total 8 articles about (4S,5S)-7-benzyloxy-5-(tert-butyldimethylsilanyloxy)-4-methyl-3-oxoheptanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 623-73-4
diazoacetic acid ethyl ester

: 375826-96-3
(2S,3S)-5-benzyloxy-3-(tert-butyldimethylsilanyloxy)-2-methylpentanoic acid ethyl ester

: 375826-97-4
(4S,5S)-7-benzyloxy-5-(tert-butyldimethylsilanyloxy)-4-methyl-3-oxoheptanoic acid ethyl ester

Guidance literature:: (2S,3S)-5-benzyloxy-3-(tert-butyldimethylsilanyloxy)-2-methylpentanoic acid ethyl ester; With diisobutylaluminium hydride;

diazoacetic acid ethyl ester; With tin(ll) chloride;
DOI:10.1002/1521-3773(20010903)40:17<3224::AID-ANIE3224>3.0.CO;2-D

Reference yield:

: 95112-81-5,113335-04-9
(S)-ethyl 5-benzyloxy-3-hydroxypentanoate

: 375826-97-4
(4S,5S)-7-benzyloxy-5-(tert-butyldimethylsilanyloxy)-4-methyl-3-oxoheptanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 78 percent / lithium diisopropylamide; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / tetrahydrofuran

2.1: 94 percent / 2,6-lutidine

3.1: DIBAL-H

3.2: 74 percent / SnCl₂

With 2,6-dimethylpyridine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; diisobutylaluminium hydride; lithium diisopropyl amide; In tetrahydrofuran; 1.1: Frater-Seebach alkylation / 3.2: Roskamp homologation;
DOI:10.1002/1521-3773(20010903)40:17<3224::AID-ANIE3224>3.0.CO;2-D

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 375826-97-4
(4S,5S)-7-benzyloxy-5-(tert-butyldimethylsilanyloxy)-4-methyl-3-oxoheptanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 94 percent / 2,6-lutidine

2.1: DIBAL-H

2.2: 74 percent / SnCl₂

With 2,6-dimethylpyridine; diisobutylaluminium hydride; 2.2: Roskamp homologation;
DOI:10.1002/1521-3773(20010903)40:17<3224::AID-ANIE3224>3.0.CO;2-D