4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-(2-fluoroethyl)-2,2-diphenylbutanamide

Base Information

Chemical Name:4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-(2-fluoroethyl)-2,2-diphenylbutanamide
CAS No.:1424272-64-9
Molecular Formula:C₂₉H₃₂ClFN₂O₂
Molecular Weight:495.037
Hs Code.:

Synonyms:4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-(2-fluoroethyl)-2,2-diphenylbutanamide

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Chemical Property of 4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-(2-fluoroethyl)-2,2-diphenylbutanamide

Chemical Property:

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Technology Process of 4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-(2-fluoroethyl)-2,2-diphenylbutanamide

There total 4 articles about 4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-(2-fluoroethyl)-2,2-diphenylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 66164-06-5
4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-2,2-diphenylbutanamide

: 95353-04-1
trifluoromethanesulfonic acid 2-fluoroethyl ester

: 1424272-64-9
4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-(2-fluoroethyl)-2,2-diphenylbutanamide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 80 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.tetlet.2012.12.121

Reference yield:

: 63959-33-1
VUF 5742

: 1424272-64-9
4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-(2-fluoroethyl)-2,2-diphenylbutanamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / tert-butyl alcohol / 72 h / 100 °C / Inert atmosphere

2: sodium hydride / N,N-dimethyl-formamide / 12 h / 80 °C / Inert atmosphere

With sodium hydride; potassium hydroxide; In N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2012.12.121

Reference yield:

: 39186-58-8
4-bromo-2,2-diphenylbutyronitrile

: 1424272-64-9
4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-(2-fluoroethyl)-2,2-diphenylbutanamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 31 h / 80 °C / Inert atmosphere

2: potassium hydroxide / tert-butyl alcohol / 72 h / 100 °C / Inert atmosphere

3: sodium hydride / N,N-dimethyl-formamide / 12 h / 80 °C / Inert atmosphere

With sodium hydride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2012.12.121