N-Didesmethyl Loperamide

Base Information

Chemical Name:N-Didesmethyl Loperamide
CAS No.:66164-06-5
Molecular Formula:C27H29 Cl N2 O2
Molecular Weight:448.992
Hs Code.:2933399090
Mol file:66164-06-5.mol

Synonyms:R21345

Suppliers and Price of N-Didesmethyl Loperamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
N-Didesmethyl Loperamide
5mg
$ 460.00

TRC
N-DidesmethylLoperamide
5mg
$ 185.00

Biosynth Carbosynth
N-Didesmethyl loperamide
2 mg
$ 495.50

Biosynth Carbosynth
N-Didesmethyl loperamide
1 mg
$ 272.60

Biosynth Carbosynth
N-Didesmethyl loperamide
10 mg
$ 1638.00

Biosynth Carbosynth
N-Didesmethyl loperamide
5 mg
$ 900.90

American Custom Chemicals Corporation
N-DIDESMETHYL LOPERAMIDE 95.00%
50MG
$ 1963.50

American Custom Chemicals Corporation
N-DIDESMETHYL LOPERAMIDE 95.00%
5MG
$ 786.50

Total 7 raw suppliers

Chemical Property of N-Didesmethyl Loperamide

Chemical Property:

Vapor Pressure:2.67E-19mmHg at 25°C
Melting Point:210-212oC
Boiling Point:677.8°C at 760 mmHg
PKA:13.85±0.20(Predicted)
Flash Point:363.7°C
PSA：67.55000
Density:1.229g/cm³
LogP:5.57270
Storage Temp.:-20°C Freezer

Purity/Quality:

97% ^*data from raw suppliers

N-Didesmethyl Loperamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses A metabolite of Loperamide; a new and improved PET radiotracer for imaging P-gp function

Technology Process of N-Didesmethyl Loperamide

There total 5 articles about N-Didesmethyl Loperamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 63959-33-1
VUF 5742

: 66164-06-5
4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-2,2-diphenylbutanamide

Guidance literature:: With potassium hydroxide; In tert-butyl alcohol; at 100 ℃; for 72h; Inert atmosphere;
DOI:10.1016/j.tetlet.2012.12.121

Reference yield: 37.0%

: 66164-06-5
4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-2,2-diphenylbutanamide

Guidance literature:

Reference yield:

: 39186-58-8
4-bromo-2,2-diphenylbutyronitrile

: 66164-06-5
4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-2,2-diphenylbutanamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h / Inert atmosphere; Schlenk technique

2: potassium hydroxide / tert-butyl alcohol / 72 h / 100 °C / Inert atmosphere; Schlenk technique

With N-ethyl-N,N-diisopropylamine; potassium hydroxide; In acetonitrile; tert-butyl alcohol;
DOI:10.3390/molecules171214288