Technology Process of ethyl (6S)-2-benzhydryl-1,7-dioxo-2-azaspiro[5.5]undecane-8-carboxylate
There total 7 articles about ethyl (6S)-2-benzhydryl-1,7-dioxo-2-azaspiro[5.5]undecane-8-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
Inert atmosphere;
DOI:10.1021/ol2033042
- Guidance literature:
-
Multi-step reaction with 7 steps
1: lithium hexamethyldisilazane / tetrahydrofuran / 4 h / -78 °C
2: Br(1-)*C56H34F6N(1+); potassium hydroxide / toluene / 24 h / -40 °C
3: dilauryl peroxide / 1,2-dichloro-ethane / 2.5 h / Inert atmosphere; Reflux
4: 2,2'-azobis(isobutyronitrile); tripropyl stannane / toluene / 3 h / Reflux
5: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
6: methanol / diethyl ether; toluene / 0.5 h / 20 °C
7: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
With
methanol; 2,2'-azobis(isobutyronitrile); dilauryl peroxide; Br(1-)*C56H34F6N(1+); tripropyl stannane; trifluoroacetic acid; potassium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; diethyl ether; dichloromethane; 1,2-dichloro-ethane; toluene;
7: Dieckmann condensation;
DOI:10.1021/ol2033042
- Guidance literature:
-
Multi-step reaction with 8 steps
1: tetrabutylammomium bromide; potassium hydroxide / toluene / 24 h / 20 °C
2: lithium hexamethyldisilazane / tetrahydrofuran / 4 h / -78 °C
3: Br(1-)*C56H34F6N(1+); potassium hydroxide / toluene / 24 h / -40 °C
4: dilauryl peroxide / 1,2-dichloro-ethane / 2.5 h / Inert atmosphere; Reflux
5: 2,2'-azobis(isobutyronitrile); tripropyl stannane / toluene / 3 h / Reflux
6: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
7: methanol / diethyl ether; toluene / 0.5 h / 20 °C
8: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
With
methanol; 2,2'-azobis(isobutyronitrile); dilauryl peroxide; Br(1-)*C56H34F6N(1+); tetrabutylammomium bromide; tripropyl stannane; trifluoroacetic acid; potassium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; diethyl ether; dichloromethane; 1,2-dichloro-ethane; toluene;
8: Dieckmann condensation;
DOI:10.1021/ol2033042
