3-(diphenylphosphoryl)-2-methylimidazo[1,2-a]pyridine hydrochloride

Base Information

• Chemical Name: 3-(diphenylphosphoryl)-2-methylimidazo[1,2-a]pyridine hydrochloride
• CAS No.: 1345964-72-8
• Molecular Formula: C₂₀H₁₇N₂OP*ClH
• Molecular Weight: 368.802
• Mol file: 1345964-72-8.mol

Synonyms:3-(diphenylphosphoryl)-2-methylimidazo[1,2-a]pyridine hydrochloride

Chemical Property of 3-(diphenylphosphoryl)-2-methylimidazo[1,2-a]pyridine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(diphenylphosphoryl)-2-methylimidazo[1,2-a]pyridine hydrochloride

There total 8 articles about 3-(diphenylphosphoryl)-2-methylimidazo[1,2-a]pyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.9%

chloro-diphenylphosphine (1079-66-9,74391-44-9) + 3-bromo-2-methylimidazo[1,2-a]pyridine (4805-70-3) → 3-(diphenylphosphoryl)-2-methylimidazo[1,2-a]pyridine hydrochloride (1345964-72-8)

Guidance literature:

3-bromo-2-methylimidazo[1,2-a]pyridine; With TurboGrignard; In tetrahydrofuran; at -15 - 10 ℃; Inert atmosphere;

chloro-diphenylphosphine; In tetrahydrofuran; at 25 ℃; Inert atmosphere;

DOI:10.1021/jm400904m

Reference yield:

3-(2-methylimidazo<1,2-a>pyridyl)diphenylphosphine → 3-(diphenylphosphoryl)-2-methylimidazo[1,2-a]pyridine hydrochloride (1345964-72-8)

Guidance literature:

3-(2-methylimidazo<1,2-a>pyridyl)diphenylphosphine; With dihydrogen peroxide; In tetrahydrofuran; water;

With hydrogenchloride; In diethyl ether; dichloromethane;

Reference yield:

chloro-diphenylphosphine (1079-66-9,74391-44-9) → 3-(diphenylphosphoryl)-2-methylimidazo[1,2-a]pyridine hydrochloride (1345964-72-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: TurboGrignard / tetrahydrofuran / -15 - 10 °C / Inert atmosphere

1.2: 10 - 20 °C / Inert atmosphere

2.1: dihydrogen peroxide / water; tetrahydrofuran

With TurboGrignard; dihydrogen peroxide; In tetrahydrofuran; water;

upstream raw materials:

3-bromo-2-methylimidazo[1,2-a]pyridine

chloro-diphenylphosphine

2-amino-1-(prop-2-yn-1-yl)pyridin-1-ium bromide

2-methylimidazo[1,2-a]pyridine