N-<(1S)-1-<(1S)-1-methylpropyl>-2-oxobutyl>-(3S)-1-benzyloxycarbonyl-2-<(2R)-2-benzyloxyaminocarbonylmethyl-1-oxoheptyl>hexahydropyridazine-3-carboxamide

Base Information

Chemical Name:N-<(1S)-1-<(1S)-1-methylpropyl>-2-oxobutyl>-(3S)-1-benzyloxycarbonyl-2-<(2R)-2-benzyloxyaminocarbonylmethyl-1-oxoheptyl>hexahydropyridazine-3-carboxamide
CAS No.:147961-59-9
Molecular Formula:C₃₇H₅₂N₄O₇
Molecular Weight:664.842
Hs Code.:

N-<(1S)-1-<(1S)-1-methylpropyl>-2-oxobutyl>-(3S)-1-benzyloxycarbonyl-2-<(2R)-2-benzyloxyaminocarbonylmethyl-1-oxoheptyl>hexahydropyridazine-3-carboxamide

Synonyms:N-<(1S)-1-<(1S)-1-methylpropyl>-2-oxobutyl>-(3S)-1-benzyloxycarbonyl-2-<(2R)-2-benzyloxyaminocarbonylmethyl-1-oxoheptyl>hexahydropyridazine-3-carboxamide

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Chemical Property of N-<(1S)-1-<(1S)-1-methylpropyl>-2-oxobutyl>-(3S)-1-benzyloxycarbonyl-2-<(2R)-2-benzyloxyaminocarbonylmethyl-1-oxoheptyl>hexahydropyridazine-3-carboxamide

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Technology Process of N-<(1S)-1-<(1S)-1-methylpropyl>-2-oxobutyl>-(3S)-1-benzyloxycarbonyl-2-<(2R)-2-benzyloxyaminocarbonylmethyl-1-oxoheptyl>hexahydropyridazine-3-carboxamide

There total 16 articles about N-<(1S)-1-<(1S)-1-methylpropyl>-2-oxobutyl>-(3S)-1-benzyloxycarbonyl-2-<(2R)-2-benzyloxyaminocarbonylmethyl-1-oxoheptyl>hexahydropyridazine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: (4S,5S)-4-amino-5-methyl-3-heptanone

: 147983-32-2
(3S)-1-benzyloxycarbonyl-2-<(2R)-2-benzyloxyaminocarbonylmethyl-1-oxoheptyl>hexahydropyridazine-3-carboxylic acid

: 147961-59-9
N-<(1S)-1-<(1S)-1-methylpropyl>-2-oxobutyl>-(3S)-1-benzyloxycarbonyl-2-<(2R)-2-benzyloxyaminocarbonylmethyl-1-oxoheptyl>hexahydropyridazine-3-carboxamide

Guidance literature:: With diethyl dicarbonate; In tetrahydrofuran; at -15 ℃; for 6h;
DOI:10.7164/antibiotics.47.1481

Reference yield:

: 3160-59-6
N-Cbz-L-Isoleucine

: 147961-59-9
N-<(1S)-1-<(1S)-1-methylpropyl>-2-oxobutyl>-(3S)-1-benzyloxycarbonyl-2-<(2R)-2-benzyloxyaminocarbonylmethyl-1-oxoheptyl>hexahydropyridazine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / DCC, iPr₂NEt, 4-dimethylaminopyridine / CH₂Cl₂ / 2 h / 0 °C

2: 56 percent / tetrahydrofuran; hexane / 1.) -15 deg C, 35 min, 2.) 0 deg C, 35 min

3: H₂ / 10percent Pd/C / methanol / 0.67 h / Ambient temperature

4: 60 percent / DEPC / tetrahydrofuran / 6 h / -15 °C

With dmap; hydrogen; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; diethyl dicarbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.7164/antibiotics.47.1481

Reference yield:

: 147961-54-4
(4S,5S)-4-(benzyloxycarbonylamino)-5-methyl-3-heptanone

: 147961-59-9
N-<(1S)-1-<(1S)-1-methylpropyl>-2-oxobutyl>-(3S)-1-benzyloxycarbonyl-2-<(2R)-2-benzyloxyaminocarbonylmethyl-1-oxoheptyl>hexahydropyridazine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / methanol / 0.67 h / Ambient temperature

2: 60 percent / DEPC / tetrahydrofuran / 6 h / -15 °C

With hydrogen; diethyl dicarbonate; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.7164/antibiotics.47.1481