Technology Process of (2S,3S,4S,6R,8R)-1-benzyloxy-8-(N-benzyloxycarbonylamino)-3,6-epoxy-2-methyl-4-(phenylseleno)undecane
There total 7 articles about (2S,3S,4S,6R,8R)-1-benzyloxy-8-(N-benzyloxycarbonylamino)-3,6-epoxy-2-methyl-4-(phenylseleno)undecane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tin(IV) chloride;
In
dichloromethane;
at 20 ℃;
for 18h;
DOI:10.1039/c2ob26801a
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C
1.2: 2 h / -78 °C
2.1: 20% palladium hydroxide-activated charcoal; ammonium formate; formic acid / methanol / 3 h / 20 °C
3.1: potassium carbonate / water; diethyl ether / 3.5 h / 0 - 20 °C
4.1: lithium aluminium tetrahydride / diethyl ether / 2.17 h / 0 - 20 °C
5.1: oxalyl dichloride; triethylamine; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 - 20 °C
6.1: tin(IV) chloride / dichloromethane / 0.08 h / -78 °C
6.2: 0.83 h / -78 °C
7.1: tin(IV) chloride / dichloromethane / 18 h / 20 °C
With
lithium aluminium tetrahydride; n-butyllithium; formic acid; oxalyl dichloride; 20% palladium hydroxide-activated charcoal; ammonium formate; tin(IV) chloride; potassium carbonate; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water;
DOI:10.1039/c2ob26801a
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 20% palladium hydroxide-activated charcoal; ammonium formate; formic acid / methanol / 3 h / 20 °C
2.1: potassium carbonate / water; diethyl ether / 3.5 h / 0 - 20 °C
3.1: lithium aluminium tetrahydride / diethyl ether / 2.17 h / 0 - 20 °C
4.1: oxalyl dichloride; triethylamine; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 - 20 °C
5.1: tin(IV) chloride / dichloromethane / 0.08 h / -78 °C
5.2: 0.83 h / -78 °C
6.1: tin(IV) chloride / dichloromethane / 18 h / 20 °C
With
lithium aluminium tetrahydride; formic acid; oxalyl dichloride; 20% palladium hydroxide-activated charcoal; ammonium formate; tin(IV) chloride; potassium carbonate; dimethyl sulfoxide; triethylamine;
In
methanol; diethyl ether; dichloromethane; water;
DOI:10.1039/c2ob26801a
