Technology Process of N(2)-acetyl-N(10)-trifluoroacetylpteroic acid
There total 5 articles about N(2)-acetyl-N(10)-trifluoroacetylpteroic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 62 percent / NaOH, H2O / 4 h / Ambient temperature
2: 2.) Me2NH*BH3 / 1.) glacial acetic acid, r.t., 15 min, 2.) glacial acetic acid, r.t., 20 min; 60 deg C, 10 min
3: 75 percent / trifluoroacetic acid / 1.5 h / Heating
With
sodium hydroxide; dimethylamine borane; water;
In
trifluoroacetic acid;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) n-BuLi / 1.) ether, hexane, -78 deg C, 2 h, 2.) ether, hexane, -78 deg C to r.t.
2: 62 percent / NaOH, H2O / 4 h / Ambient temperature
3: 2.) Me2NH*BH3 / 1.) glacial acetic acid, r.t., 15 min, 2.) glacial acetic acid, r.t., 20 min; 60 deg C, 10 min
4: 75 percent / trifluoroacetic acid / 1.5 h / Heating
With
sodium hydroxide; n-butyllithium; dimethylamine borane; water;
In
trifluoroacetic acid;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 2.) Me2NH*BH3 / 1.) glacial acetic acid, r.t., 15 min, 2.) glacial acetic acid, r.t., 20 min; 60 deg C, 10 min
2: 75 percent / trifluoroacetic acid / 1.5 h / Heating
With
dimethylamine borane;
In
trifluoroacetic acid;
