PTEROIC ACID

Base Information

• Chemical Name: PTEROIC ACID
• CAS No.: 119-24-4
• Molecular Formula: C14H12 N6 O3
• Molecular Weight: 312.288
• Hs Code.: 2933990090
• Mol file: 119-24-4.mol

Synonyms:Benzoicacid, 4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]- (9CI); Benzoicacid, p-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]- (6CI); Pteroicacid (7CI,8CI); NSC 14972; p-[(2-Amino-4-hydroxy-6-pteridylmethyl)amino]benzoicacid

Chemical Property of PTEROIC ACID

Chemical Property:

• Vapor Pressure: 2.61E-18mmHg at 25°C
• Melting Point: >400℃
• Boiling Point: 659.8°Cat760mmHg
• PKA: 4.65±0.10(Predicted)
• Flash Point: 352.9°C
• PSA: 147.14000
• Density: 1.69g/cm³
• LogP: 1.67210
• Storage Temp.: 2-8°C
• Solubility.: Aqueous Base (Slightly), DMSO (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

Pteroic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Pteroic Acid is a constituent as well as a degradation product of Folid Acid (F680300) formed via anzymatic hydrolysis. has been shown to activate the glutamylation of methotrexate by folylpolyglutama te synthetase. Pteroic Acid (Methotrexate EP Impurity D N-Desmethyl Impurity) is a constituent as well as a degradation product of Folic Acid (F680300) formed via enzymatic hydrolysis. has been shown to activate the glutamylation of methotrexate by folylpolyglutamate synthetase.

Technology Process of PTEROIC ACID

There total 32 articles about PTEROIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.7%

folate (65165-92-6) → pteroic acid (119-24-4)

Guidance literature:

With hydrogenchloride; carboxypeptidase G; Tris buffer; zinc(II) chloride; for 120h; Ambient temperature;

DOI:10.1021/jm00085a010

Reference yield: 68.0%

pyrofolic acid (223378-69-6) → folate (65165-92-6) + pteroic acid (119-24-4)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja971568j

Reference yield: 52.0%

N10-(trifluoroacetyl)pyrofolic acid (223378-68-5) → folate (65165-92-6) + pteroic acid (119-24-4)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja971568j

upstream raw materials:

2,5,6-triamino-3,4-dihydro-4-pyrimidinone

2,3-dibromopropanal

4-amino-benzoic acid

1,1,3-tribromoacetone

Downstream raw materials:

(6-([4-(imidazol-1-ylcarbonyl)phenylamino]methyl)-4-oxo-3,4-dihydro-pteridin-2-yl)-carbamic acid 2-trimethylsilylethyl ester

N-{2-[2-(2-amino-ethoxy)-ethoxy]-ethyl}-4-[(2-amino-4-hydroxy-pteridin-6-ylmethyl)-amino]-benzamide

N₁₀-trifluoroacetylpteroic acid

N¹⁰-(trifluoroacetyl)pteroic acid

Refernces

• 1、 Plante. "-". . p. 860. Retrieved 1971.
• 2、 Dawadi, Surendra,Kordus, Shannon L.,Baughn, Anthony D.,Aldrich, Courtney C.. "Synthesis and analysis of bacterial folate metabolism intermediates and antifolates". supporting information. p. 5220 - 5223. Retrieved 2017/11/06.
• 3、 -. "POSITRON EMISSION TOMOGRAPHY IMAGING METHOD". Page/Page column 30-31. . Retrieved 2008/12/08.