2-bromo-5-{[3-hexoxymethyl-5-({3-(tetrahydropyran-2-yloxymethyl)-5-[(triisopropylsilyl)ethynyl]phenyl}ethynyl)phenyl]ethynyl}pyridine

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Chemical Name:2-bromo-5-{[3-hexoxymethyl-5-({3-(tetrahydropyran-2-yloxymethyl)-5-[(triisopropylsilyl)ethynyl]phenyl}ethynyl)phenyl]ethynyl}pyridine
CAS No.:569672-41-9
Molecular Formula:C₄₅H₅₆BrNO₃Si
Molecular Weight:766.934
Hs Code.:

Synonyms:2-bromo-5-{[3-hexoxymethyl-5-({3-(tetrahydropyran-2-yloxymethyl)-5-[(triisopropylsilyl)ethynyl]phenyl}ethynyl)phenyl]ethynyl}pyridine

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Chemical Property of 2-bromo-5-{[3-hexoxymethyl-5-({3-(tetrahydropyran-2-yloxymethyl)-5-[(triisopropylsilyl)ethynyl]phenyl}ethynyl)phenyl]ethynyl}pyridine

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Technology Process of 2-bromo-5-{[3-hexoxymethyl-5-({3-(tetrahydropyran-2-yloxymethyl)-5-[(triisopropylsilyl)ethynyl]phenyl}ethynyl)phenyl]ethynyl}pyridine

There total 7 articles about 2-bromo-5-{[3-hexoxymethyl-5-({3-(tetrahydropyran-2-yloxymethyl)-5-[(triisopropylsilyl)ethynyl]phenyl}ethynyl)phenyl]ethynyl}pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 73290-22-9
2-bromo-5-iodo-pyridine

: 569672-40-8
1-hexoxymethyl-3-({3-(tetrahydropyran-2-yloxymethyl)-5-[(triisopropylsilyl)ethynyl]phenyl}ethynyl)-5-ethynylbenzene

: 569672-41-9
2-bromo-5-{[3-hexoxymethyl-5-({3-(tetrahydropyran-2-yloxymethyl)-5-[(triisopropylsilyl)ethynyl]phenyl}ethynyl)phenyl]ethynyl}pyridine

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; at 60 ℃; for 72h;
DOI:10.1021/ja034029p

Reference yield:

: 89343-06-6
tris-iso-propylsilyl acetylene

: 569672-41-9
2-bromo-5-{[3-hexoxymethyl-5-({3-(tetrahydropyran-2-yloxymethyl)-5-[(triisopropylsilyl)ethynyl]phenyl}ethynyl)phenyl]ethynyl}pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / Et₃N; Pd[P(Ph₃)]4; CuI / 72 h / 80 °C

2: 98 percent / aq. NaOH / CH₂Cl₂; methanol

3: 61 percent / Et₃N; Pd(PPh₃)4; CuI / 72 h / 70 °C

4: 86 percent / aq. NaOH / methanol; CH₂Cl₂

5: 93 percent / Et₃N; Pd[P(Ph₃)]4; CuI / 72 h / 60 °C

With sodium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In methanol; dichloromethane; 1: Sonogashira cross-coupling / 3: Sonogashira cross-coupling / 5: Sonogashira cross-coupling;
DOI:10.1021/ja034029p

Reference yield:

: 225932-17-2
2-(3-Bromo-5-iodobenzyloxy)tetrahydropyran

: 569672-41-9
2-bromo-5-{[3-hexoxymethyl-5-({3-(tetrahydropyran-2-yloxymethyl)-5-[(triisopropylsilyl)ethynyl]phenyl}ethynyl)phenyl]ethynyl}pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / Et₃N; CuI; Pd(PPh₃)4 / 96 h / 60 °C

2: 72 percent / Et₃N; Pd[P(Ph₃)]4; CuI / 72 h / 80 °C

3: 98 percent / aq. NaOH / CH₂Cl₂; methanol

4: 61 percent / Et₃N; Pd(PPh₃)4; CuI / 72 h / 70 °C

5: 86 percent / aq. NaOH / methanol; CH₂Cl₂

6: 93 percent / Et₃N; Pd[P(Ph₃)]4; CuI / 72 h / 60 °C

With sodium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In methanol; dichloromethane; 1: Sonogashira cross-coupling / 2: Sonogashira cross-coupling / 4: Sonogashira cross-coupling / 6: Sonogashira cross-coupling;
DOI:10.1021/ja034029p