1-hexoxymethyl-3-({3-(tetrahydropyran-2-yloxymethyl)-5-[(triisopropylsilyl)ethynyl]phenyl}ethynyl)-5-ethynylbenzene

Base Information

Chemical Name:1-hexoxymethyl-3-({3-(tetrahydropyran-2-yloxymethyl)-5-[(triisopropylsilyl)ethynyl]phenyl}ethynyl)-5-ethynylbenzene
CAS No.:569672-40-8
Molecular Formula:C₄₀H₅₄O₃Si
Molecular Weight:610.952
Hs Code.:

Synonyms:1-hexoxymethyl-3-({3-(tetrahydropyran-2-yloxymethyl)-5-[(triisopropylsilyl)ethynyl]phenyl}ethynyl)-5-ethynylbenzene

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Chemical Property of 1-hexoxymethyl-3-({3-(tetrahydropyran-2-yloxymethyl)-5-[(triisopropylsilyl)ethynyl]phenyl}ethynyl)-5-ethynylbenzene

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Technology Process of 1-hexoxymethyl-3-({3-(tetrahydropyran-2-yloxymethyl)-5-[(triisopropylsilyl)ethynyl]phenyl}ethynyl)-5-ethynylbenzene

There total 6 articles about 1-hexoxymethyl-3-({3-(tetrahydropyran-2-yloxymethyl)-5-[(triisopropylsilyl)ethynyl]phenyl}ethynyl)-5-ethynylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 569672-39-5
1-hexoxymethyl-3-({3-(tetrahydropyran-2-yloxymethyl)-5-[(triisopropylsilyl)ethynyl]phenyl}ethynyl)-5-[(trimethylsilyl)ethynyl]benzene

: 569672-40-8
1-hexoxymethyl-3-({3-(tetrahydropyran-2-yloxymethyl)-5-[(triisopropylsilyl)ethynyl]phenyl}ethynyl)-5-ethynylbenzene

Guidance literature:: With sodium hydroxide; In methanol; dichloromethane;
DOI:10.1021/ja034029p

Reference yield:

: 89343-06-6
tris-iso-propylsilyl acetylene

: 569672-40-8
1-hexoxymethyl-3-({3-(tetrahydropyran-2-yloxymethyl)-5-[(triisopropylsilyl)ethynyl]phenyl}ethynyl)-5-ethynylbenzene

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / Et₃N; Pd[P(Ph₃)]4; CuI / 72 h / 80 °C

2: 98 percent / aq. NaOH / CH₂Cl₂; methanol

3: 61 percent / Et₃N; Pd(PPh₃)4; CuI / 72 h / 70 °C

4: 86 percent / aq. NaOH / methanol; CH₂Cl₂

With sodium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In methanol; dichloromethane; 1: Sonogashira cross-coupling / 3: Sonogashira cross-coupling;
DOI:10.1021/ja034029p

Reference yield:

: 225932-17-2
2-(3-Bromo-5-iodobenzyloxy)tetrahydropyran

: 569672-40-8
1-hexoxymethyl-3-({3-(tetrahydropyran-2-yloxymethyl)-5-[(triisopropylsilyl)ethynyl]phenyl}ethynyl)-5-ethynylbenzene

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / Et₃N; CuI; Pd(PPh₃)4 / 96 h / 60 °C

2: 72 percent / Et₃N; Pd[P(Ph₃)]4; CuI / 72 h / 80 °C

3: 98 percent / aq. NaOH / CH₂Cl₂; methanol

4: 61 percent / Et₃N; Pd(PPh₃)4; CuI / 72 h / 70 °C

5: 86 percent / aq. NaOH / methanol; CH₂Cl₂

With sodium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In methanol; dichloromethane; 1: Sonogashira cross-coupling / 2: Sonogashira cross-coupling / 4: Sonogashira cross-coupling;
DOI:10.1021/ja034029p