8-(2-chlorophenyl)-8-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-2,2-dimethyloctanoic acid

Base Information

Chemical Name:8-(2-chlorophenyl)-8-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-2,2-dimethyloctanoic acid
CAS No.:1373491-57-6
Molecular Formula:C₂₃H₃₀ClNO₂S
Molecular Weight:420.016
Hs Code.:

Synonyms:8-(2-chlorophenyl)-8-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-2,2-dimethyloctanoic acid

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Chemical Property of 8-(2-chlorophenyl)-8-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-2,2-dimethyloctanoic acid

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Technology Process of 8-(2-chlorophenyl)-8-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-2,2-dimethyloctanoic acid

There total 3 articles about 8-(2-chlorophenyl)-8-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-2,2-dimethyloctanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.8%

: 1373491-79-2
8-(2-chlorophenyl)-8-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-2,2-dimethyloctanoic acid ethyl ester

: 1373491-57-6
8-(2-chlorophenyl)-8-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-2,2-dimethyloctanoic acid

Guidance literature:: 8-(2-chlorophenyl)-8-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-2,2-dimethyloctanoic acid ethyl ester; With water; sodium hydroxide; In ethanol; for 6.5h; Reflux;

With hydrogenchloride; In water; pH=6;

Reference yield:

: 123469-92-1
ethyl-2,2-dimethyl-7-bromoheptanoate

: 1373491-57-6
8-(2-chlorophenyl)-8-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-2,2-dimethyloctanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene / 24 h / 122 °C

2.1: sodium hydroxide / dichloromethane

3.1: hydrogen bromide; acetic acid / 8 h / 15 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 65 - 70 °C

5.1: sodium hydroxide; water / ethanol / 6.5 h / Reflux

5.2: pH 6

With water; hydrogen bromide; potassium carbonate; acetic acid; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1373492-36-4
8-(2-chlorophenyl)-2,2-dimethyloct-7-enoic acid ethyl ester

: 1373491-57-6
8-(2-chlorophenyl)-8-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-2,2-dimethyloctanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen bromide; acetic acid / 8 h / 15 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 65 - 70 °C

3.1: sodium hydroxide; water / ethanol / 6.5 h / Reflux

3.2: pH 6

With water; hydrogen bromide; potassium carbonate; acetic acid; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;