(RS)-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-S-methyl-N-(trifluoroacetyl)sulfoximide

Base Information

Chemical Name:(RS)-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-S-methyl-N-(trifluoroacetyl)sulfoximide
CAS No.:1223498-95-0
Molecular Formula:C₁₈H₁₈F₆N₄O₄S
Molecular Weight:500.422
Hs Code.:

Synonyms:(RS)-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-S-methyl-N-(trifluoroacetyl)sulfoximide

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Chemical Property of (RS)-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-S-methyl-N-(trifluoroacetyl)sulfoximide

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Technology Process of (RS)-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-S-methyl-N-(trifluoroacetyl)sulfoximide

There total 5 articles about (RS)-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-S-methyl-N-(trifluoroacetyl)sulfoximide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1223498-53-0
(RS)-S-(4-{[4-{[(1R,2R)-2-(benzyloxy)-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-S-methyl-N-(trifluoroacetyl)sulfoximide

: 1223498-95-0
(RS)-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-S-methyl-N-(trifluoroacetyl)sulfoximide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; under 760.051 Torr;

Reference yield:

: 940-12-5
p-nitrophenyl methyl sulfoxide

: 1223498-95-0
(RS)-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-S-methyl-N-(trifluoroacetyl)sulfoximide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium azide; sulfuric acid / dichloromethane / 16 h / 0 - 45 °C

1.2: pH 11

2.1: dmap; triethylamine / dichloromethane / 2 h / cooling with ice

3.1: hydrogen / palladium 10% on activated carbon / di-isopropyl ether; ethanol; tetrahydrofuran / 0.75 h / 24 °C / 760.05 Torr

4.1: hydrogenchloride / 1,4-dioxane; acetonitrile / 6 h / 80 °C

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / 760.05 Torr

With hydrogenchloride; dmap; sodium azide; sulfuric acid; hydrogen; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; di-isopropyl ether; acetonitrile;

Reference yield:

: 1223498-47-2
4-{[(1R,2R)-2-(benzyloxy)-1-methylpropyl]oxy}-2-chloro-5-iodopyrimidine

: 1223498-95-0
(RS)-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-S-methyl-N-(trifluoroacetyl)sulfoximide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium fluoride; copper(l) iodide / 1-methyl-pyrrolidin-2-one; tetrahydrofuran / 5.5 h / 20 - 80 °C

2: hydrogenchloride / 1,4-dioxane; acetonitrile / 6 h / 80 °C

3: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / 760.05 Torr

With hydrogenchloride; potassium fluoride; copper(l) iodide; hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; acetonitrile;