4-{[(1R,2R)-2-(benzyloxy)-1-methylpropyl]oxy}-2-chloro-5-iodopyrimidine

Base Information

Chemical Name:4-{[(1R,2R)-2-(benzyloxy)-1-methylpropyl]oxy}-2-chloro-5-iodopyrimidine
CAS No.:1223498-47-2
Molecular Formula:C₁₅H₁₆ClIN₂O₂
Molecular Weight:418.662
Hs Code.:

Synonyms:4-{[(1R,2R)-2-(benzyloxy)-1-methylpropyl]oxy}-2-chloro-5-iodopyrimidine

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Chemical Property of 4-{[(1R,2R)-2-(benzyloxy)-1-methylpropyl]oxy}-2-chloro-5-iodopyrimidine

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Technology Process of 4-{[(1R,2R)-2-(benzyloxy)-1-methylpropyl]oxy}-2-chloro-5-iodopyrimidine

There total 2 articles about 4-{[(1R,2R)-2-(benzyloxy)-1-methylpropyl]oxy}-2-chloro-5-iodopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 124338-52-9
(2R,3R)-3-(phenylmethoxy)-2-butanol

: 13544-44-0
2,4-dichloro-5-iodopyrimidine

: 1223498-47-2
4-{[(1R,2R)-2-(benzyloxy)-1-methylpropyl]oxy}-2-chloro-5-iodopyrimidine

Guidance literature:: (2R,3R)-3-(phenylmethoxy)-2-butanol; With sodium hydride; In diethyl ether; mineral oil; at 0 - 20 ℃; for 0.216667h;

2,4-dichloro-5-iodopyrimidine; In diethyl ether; acetonitrile; mineral oil; at 0 - 40 ℃;

Reference yield:

: 100-39-0
benzyl bromide

: 1223498-47-2
4-{[(1R,2R)-2-(benzyloxy)-1-methylpropyl]oxy}-2-chloro-5-iodopyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / Reflux

1.2: 20 °C / Reflux

2.1: sodium hydride / diethyl ether; mineral oil / 0.22 h / 0 - 20 °C

2.2: 0 - 40 °C

With potassium tert-butylate; sodium hydride; In tetrahydrofuran; diethyl ether; mineral oil;