N-(2-{3-[3,5-bis(trifluoromethyl)phenyl]ureido}ethyl)glycyrrhetinamide

Base Information

Chemical Name:N-(2-{3-[3,5-bis(trifluoromethyl)phenyl]ureido}ethyl)glycyrrhetinamide
CAS No.:1334318-82-9
Molecular Formula:C₄₁H₅₅F₆N₃O₄
Molecular Weight:767.896
Hs Code.:

Synonyms:N-(2-{3-[3,5-bis(trifluoromethyl)phenyl]ureido}ethyl)glycyrrhetinamide

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Chemical Property of N-(2-{3-[3,5-bis(trifluoromethyl)phenyl]ureido}ethyl)glycyrrhetinamide

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Technology Process of N-(2-{3-[3,5-bis(trifluoromethyl)phenyl]ureido}ethyl)glycyrrhetinamide

There total 4 articles about N-(2-{3-[3,5-bis(trifluoromethyl)phenyl]ureido}ethyl)glycyrrhetinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1360816-01-8
1-(2-aminoethyl)-3-(3,5-bis(trifluoromethyl)phenyl)urea

: 471-53-4
enoxolone

: 1334318-82-9
N-(2-{3-[3,5-bis(trifluoromethyl)phenyl]ureido}ethyl)glycyrrhetinamide

Guidance literature:: enoxolone; With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; for 0.166667h;

1-(2-aminoethyl)-3-(3,5-bis(trifluoromethyl)phenyl)urea; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1111/j.2042-7158.2012.01603.x

Reference yield: 76.0%

: 912541-99-2
N-(2-aminoethyl)-3β-hydroxy-11-oxo-olean-12-en-30-amide

: 16588-74-2
3,5-ditrifluoromethylisocyanate

: 1334318-82-9
N-(2-{3-[3,5-bis(trifluoromethyl)phenyl]ureido}ethyl)glycyrrhetinamide

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 10h;
DOI:10.1016/j.bmcl.2012.04.049

Reference yield:

: 1334318-59-0
N-[2-(tert-butoxycarbonylamino)ethyl]glycyrrhetinamide

: 1334318-82-9
N-(2-{3-[3,5-bis(trifluoromethyl)phenyl]ureido}ethyl)glycyrrhetinamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 0 °C

2: tetrahydrofuran / 20 h / 20 °C

With trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm200285z