3-[4-hydroxy-3-(1-oxo-1,3-thiazolidine-3-carbonyl)-5-trifluoromethylbenzoyl]-1,1-dioxo-2,3-dihydro-1,3-benzothiazole

Base Information

Chemical Name:3-[4-hydroxy-3-(1-oxo-1,3-thiazolidine-3-carbonyl)-5-trifluoromethylbenzoyl]-1,1-dioxo-2,3-dihydro-1,3-benzothiazole
CAS No.:1285573-18-3
Molecular Formula:C₁₉H₁₅F₃N₂O₆S₂
Molecular Weight:488.465
Hs Code.:

Synonyms:3-[4-hydroxy-3-(1-oxo-1,3-thiazolidine-3-carbonyl)-5-trifluoromethylbenzoyl]-1,1-dioxo-2,3-dihydro-1,3-benzothiazole

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Chemical Property of 3-[4-hydroxy-3-(1-oxo-1,3-thiazolidine-3-carbonyl)-5-trifluoromethylbenzoyl]-1,1-dioxo-2,3-dihydro-1,3-benzothiazole

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Technology Process of 3-[4-hydroxy-3-(1-oxo-1,3-thiazolidine-3-carbonyl)-5-trifluoromethylbenzoyl]-1,1-dioxo-2,3-dihydro-1,3-benzothiazole

There total 18 articles about 3-[4-hydroxy-3-(1-oxo-1,3-thiazolidine-3-carbonyl)-5-trifluoromethylbenzoyl]-1,1-dioxo-2,3-dihydro-1,3-benzothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1285573-17-2
3-[4-hydroxy-3-(1,3-thiazolidine-3-carbonyl)-5-trifluoromethylbenzoyl]-1,1-dioxo-2,3-dihydro-1,3-benzothiazole

: 1285573-18-3
3-[4-hydroxy-3-(1-oxo-1,3-thiazolidine-3-carbonyl)-5-trifluoromethylbenzoyl]-1,1-dioxo-2,3-dihydro-1,3-benzothiazole

Guidance literature:: With Oxone; In tetrahydrofuran; water; at 20 ℃; for 1h;

Reference yield:

: 4433-52-7
2,3-dihydro-benzothiazole

: 1285573-18-3
3-[4-hydroxy-3-(1-oxo-1,3-thiazolidine-3-carbonyl)-5-trifluoromethylbenzoyl]-1,1-dioxo-2,3-dihydro-1,3-benzothiazole

Guidance literature:: Multi-step reaction with 8 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / 20 °C

2: Amberlyst-15 / ethanol / 3.5 h / Reflux

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

4: hydrogenchloride / ethyl acetate / 2 h / 20 °C

5: sodium chlorite; 2-methyl-but-2-ene; citric acid / methanol; water / 1 h / 20 °C

6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 19 h / 20 °C

7: lithium chloride / N,N-dimethyl-formamide / 1.5 h / 120 °C

8: Oxone / tetrahydrofuran; water / 1 h / 20 °C

With hydrogenchloride; Oxone; sodium chlorite; 2-methyl-but-2-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; citric acid; lithium chloride; Amberlyst-15; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 444-30-4
2-(trifluoromethyl)phenol

: 1285573-18-3
3-[4-hydroxy-3-(1-oxo-1,3-thiazolidine-3-carbonyl)-5-trifluoromethylbenzoyl]-1,1-dioxo-2,3-dihydro-1,3-benzothiazole

Guidance literature:: Multi-step reaction with 16 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h

2.1: n-butyllithium / tetrahydrofuran; hexane / 1.75 h / -70 °C / Inert atmosphere

2.2: 0.5 h / 20 °C

3.1: hydrogenchloride; water / tetrahydrofuran; hexane / 16 h / 60 °C

4.1: N-Bromosuccinimide / acetonitrile / 1 h / 0 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

6.1: Amberlyst-15 / hexane / 3 h / Reflux

7.1: magnesium / tetrahydrofuran / 1.5 h / 20 °C

7.2: 1 h / 0 °C

7.3: 16 h / 20 °C

8.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 6.5 h / 60 °C

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / 20 °C

10.1: Amberlyst-15 / ethanol / 3.5 h / Reflux

11.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

12.1: hydrogenchloride / ethyl acetate / 2 h / 20 °C

13.1: sodium chlorite; 2-methyl-but-2-ene; citric acid / methanol; water / 1 h / 20 °C

14.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 19 h / 20 °C

15.1: lithium chloride / N,N-dimethyl-formamide / 1.5 h / 120 °C

16.1: Oxone / tetrahydrofuran; water / 1 h / 20 °C

With hydrogenchloride; Oxone; sodium chlorite; N-Bromosuccinimide; n-butyllithium; thionyl chloride; 2-methyl-but-2-ene; water; potassium carbonate; magnesium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; citric acid; lithium chloride; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;