(ethyl carbonic) (R)-5-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic anhydride

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Chemical Name:(ethyl carbonic) (R)-5-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic anhydride
CAS No.:1364889-78-0
Molecular Formula:C₂₀H₁₇F₃N₄O₄
Molecular Weight:434.375
Hs Code.:

Synonyms:(ethyl carbonic) (R)-5-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic anhydride

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Chemical Property of (ethyl carbonic) (R)-5-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic anhydride

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Technology Process of (ethyl carbonic) (R)-5-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic anhydride

There total 2 articles about (ethyl carbonic) (R)-5-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1364890-54-9
(R)-5-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

: 541-41-3
chloroformic acid ethyl ester

: 1364889-78-0
(ethyl carbonic) (R)-5-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic anhydride

Guidance literature:: With triethylamine; In tetrahydrofuran; at -5 ℃; for 0.75h;

Reference yield:

: 1364890-65-2
(R)-ethyl 5-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

: 1364889-78-0
(ethyl carbonic) (R)-5-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic anhydride

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / tetrahydrofuran; methanol / 12 h / 60 °C

2: triethylamine / tetrahydrofuran / 0.75 h / -5 °C

With water; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol;