acetic acid 4-{2-benzyloxy-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-2-methyl-but-2-enyl ester

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Chemical Name:acetic acid 4-{2-benzyloxy-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-2-methyl-but-2-enyl ester
CAS No.:850312-57-1
Molecular Formula:C₂₈H₄₀O₄Si
Molecular Weight:468.709
Hs Code.:

acetic acid 4-{2-benzyloxy-5-[1-(<i>tert</i>-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-2-methyl-but-2-enyl ester

Synonyms:acetic acid 4-{2-benzyloxy-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-2-methyl-but-2-enyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of acetic acid 4-{2-benzyloxy-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-2-methyl-but-2-enyl ester

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Technology Process of acetic acid 4-{2-benzyloxy-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-2-methyl-but-2-enyl ester

There total 7 articles about acetic acid 4-{2-benzyloxy-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-2-methyl-but-2-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 850312-56-0
Acetic acid (E)-4-[2-benzyloxy-5-(1-hydroxy-ethyl)-phenyl]-2-methyl-but-2-enyl ester

: 850312-57-1
acetic acid 4-{2-benzyloxy-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-2-methyl-but-2-enyl ester

Guidance literature:: With 1H-imidazole; dmap; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.tetasy.2005.01.011

Reference yield:

: 1838-94-4
isoprene epoxide

: 850312-57-1
acetic acid 4-{2-benzyloxy-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-2-methyl-but-2-enyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / Pd(PPh₃) / CH₂Cl₂ / 4 h / 20 °C

2: 98 percent / Et₃N; DMAP / ethyl acetate / 4 h / 20 °C

3: 98 percent / HCl / CH₂Cl₂ / 0.03 h / 20 °C

4: 92 percent / K₂CO₃ / acetone / 12 h / Heating

5: 90 percent / NaBH₄ / methanol / 2 h / 0 °C

6: 90 percent / imidazole; DMAP / CH₂Cl₂ / 0 - 20 °C

With 1H-imidazole; hydrogenchloride; dmap; sodium tetrahydroborate; potassium carbonate; triethylamine; Pd(PPh₃); In methanol; dichloromethane; ethyl acetate; acetone; 3: Claisen rearrangement;
DOI:10.1016/j.tetasy.2005.01.011

Reference yield:

: 99-93-4
4-Hydroxyacetophenone

: 850312-57-1
acetic acid 4-{2-benzyloxy-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-2-methyl-but-2-enyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / Pd(PPh₃) / CH₂Cl₂ / 4 h / 20 °C

2: 98 percent / Et₃N; DMAP / ethyl acetate / 4 h / 20 °C

3: 98 percent / HCl / CH₂Cl₂ / 0.03 h / 20 °C

4: 92 percent / K₂CO₃ / acetone / 12 h / Heating

5: 90 percent / NaBH₄ / methanol / 2 h / 0 °C

6: 90 percent / imidazole; DMAP / CH₂Cl₂ / 0 - 20 °C

With 1H-imidazole; hydrogenchloride; dmap; sodium tetrahydroborate; potassium carbonate; triethylamine; Pd(PPh₃); In methanol; dichloromethane; ethyl acetate; acetone; 3: Claisen rearrangement;
DOI:10.1016/j.tetasy.2005.01.011