2-(3-amino-4-pyridinyl)-4-(trifluoromethyl)benzoic acid hydrazide hydrochloride

Base Information

Chemical Name:2-(3-amino-4-pyridinyl)-4-(trifluoromethyl)benzoic acid hydrazide hydrochloride
CAS No.:121845-43-0
Molecular Formula:C₁₃H₁₁F₃N₄O*ClH
Molecular Weight:332.713
Hs Code.:

Synonyms:2-(3-amino-4-pyridinyl)-4-(trifluoromethyl)benzoic acid hydrazide hydrochloride

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Chemical Property of 2-(3-amino-4-pyridinyl)-4-(trifluoromethyl)benzoic acid hydrazide hydrochloride

Chemical Property:

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Technology Process of 2-(3-amino-4-pyridinyl)-4-(trifluoromethyl)benzoic acid hydrazide hydrochloride

There total 5 articles about 2-(3-amino-4-pyridinyl)-4-(trifluoromethyl)benzoic acid hydrazide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5435-54-1
4-hydroxy-3-nitropyridine

: 121845-43-0
2-(3-amino-4-pyridinyl)-4-(trifluoromethyl)benzoic acid hydrazide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / PCl₅, POCl₃ / 6 h / 130 - 140 °C

2: 77 percent / N₂H₄*H₂O / ethanol / 1.) 0 deg C, 0.75 h, 2.) 25 deg C, 3.5 h

3: 13.8 g / tetrahydrofuran / 1.) 0 deg C, 1.5 h, 2.) 25 deg C, overnight

4: 13.6 g / H₂ / 5percent Pd/C / aq. ethanol / 2327.2 Torr

With phosphorus pentachloride; hydrogen; hydrazine hydrate; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00131a010

Reference yield:

: 121845-42-9
4-Trifluoromethyl-benzoic acid N'-(3-nitro-pyridin-4-yl)-hydrazide; hydrochloride

: 121845-43-0
2-(3-amino-4-pyridinyl)-4-(trifluoromethyl)benzoic acid hydrazide hydrochloride

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; under 2327.2 Torr;
DOI:10.1021/jm00131a010

Reference yield:

: 626-64-2,157061-69-3
pyridin-4-ol

: 121845-43-0
2-(3-amino-4-pyridinyl)-4-(trifluoromethyl)benzoic acid hydrazide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / HNO₃, H₂SO₄, SO₃ / 1 h / Heating

2: 87 percent / PCl₅, POCl₃ / 6 h / 130 - 140 °C

3: 77 percent / N₂H₄*H₂O / ethanol / 1.) 0 deg C, 0.75 h, 2.) 25 deg C, 3.5 h

4: 13.8 g / tetrahydrofuran / 1.) 0 deg C, 1.5 h, 2.) 25 deg C, overnight

5: 13.6 g / H₂ / 5percent Pd/C / aq. ethanol / 2327.2 Torr

With phosphorus pentachloride; sulfuric acid; sulfur trioxide; hydrogen; nitric acid; hydrazine hydrate; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00131a010