4-Trifluoromethyl-benzoic acid N'-(3-nitro-pyridin-4-yl)-hydrazide; hydrochloride

Base Information

Chemical Name:4-Trifluoromethyl-benzoic acid N'-(3-nitro-pyridin-4-yl)-hydrazide; hydrochloride
CAS No.:121845-42-9
Molecular Formula:C₁₃H₉F₃N₄O₃*ClH
Molecular Weight:362.696
Hs Code.:

Synonyms:4-Trifluoromethyl-benzoic acid N'-(3-nitro-pyridin-4-yl)-hydrazide; hydrochloride

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Chemical Property of 4-Trifluoromethyl-benzoic acid N'-(3-nitro-pyridin-4-yl)-hydrazide; hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of 4-Trifluoromethyl-benzoic acid N'-(3-nitro-pyridin-4-yl)-hydrazide; hydrochloride

There total 3 articles about 4-Trifluoromethyl-benzoic acid N'-(3-nitro-pyridin-4-yl)-hydrazide; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5435-54-1
4-hydroxy-3-nitropyridine

: 121845-42-9
4-Trifluoromethyl-benzoic acid N'-(3-nitro-pyridin-4-yl)-hydrazide; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / PCl₅, POCl₃ / 6 h / 130 - 140 °C

2: 77 percent / N₂H₄*H₂O / ethanol / 1.) 0 deg C, 0.75 h, 2.) 25 deg C, 3.5 h

3: 13.8 g / tetrahydrofuran / 1.) 0 deg C, 1.5 h, 2.) 25 deg C, overnight

With phosphorus pentachloride; hydrazine hydrate; trichlorophosphate; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00131a010

Reference yield:

: 626-64-2,157061-69-3
pyridin-4-ol

: 121845-42-9
4-Trifluoromethyl-benzoic acid N'-(3-nitro-pyridin-4-yl)-hydrazide; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / HNO₃, H₂SO₄, SO₃ / 1 h / Heating

2: 87 percent / PCl₅, POCl₃ / 6 h / 130 - 140 °C

3: 77 percent / N₂H₄*H₂O / ethanol / 1.) 0 deg C, 0.75 h, 2.) 25 deg C, 3.5 h

4: 13.8 g / tetrahydrofuran / 1.) 0 deg C, 1.5 h, 2.) 25 deg C, overnight

With phosphorus pentachloride; sulfuric acid; sulfur trioxide; nitric acid; hydrazine hydrate; trichlorophosphate; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00131a010

Reference yield:

: 13091-23-1
4-chloro-3-nitropyridine

: 121845-42-9
4-Trifluoromethyl-benzoic acid N'-(3-nitro-pyridin-4-yl)-hydrazide; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / N₂H₄*H₂O / ethanol / 1.) 0 deg C, 0.75 h, 2.) 25 deg C, 3.5 h

2: 13.8 g / tetrahydrofuran / 1.) 0 deg C, 1.5 h, 2.) 25 deg C, overnight

With hydrazine hydrate; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00131a010