2-ethyl-6-nitroanilide

Base Information

• Chemical Name: 2-ethyl-6-nitroanilide
• CAS No.: 59816-94-3
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.18
• Mol file: 59816-94-3.mol

Synonyms:2-ethyl-6-nitroanilide

Chemical Property of 2-ethyl-6-nitroanilide

Chemical Property:

• Melting Point: 30-31 °C
• Boiling Point: 146-149 °C(Press: 5 Torr)
• Density: 1.218±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

2-Ethyl-6-nitroaniline 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-ethyl-6-nitroanilide

There total 6 articles about 2-ethyl-6-nitroanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.1%

N-(2-ethyl-6-nitrophenyl)acetamide (103150-73-8) → 2-ethyl-6-nitroanilide (59816-94-3)

Guidance literature:

With hydrogenchloride; In water;

Reference yield: 77.0%

Ethyl boronic acid (4433-63-0) + 2-bromo-6-nitroaniline (59255-95-7) → 2-ethyl-6-nitroanilide (59816-94-3)

Guidance literature:

With tripotassium phosphate tribasic; palladium diacetate; tricyclohexylphosphine; In water monomer; toluene; at 90 ℃; for 8h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.2c00096

Reference yield:

ortho-ethylaniline (578-54-1) → 2-ethyl-6-nitroanilide (59816-94-3)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid

2: acetic acid; HNO₃ / folgenden Hydrolysieren des Reaktionsprodukts

With nitric acid; acetic acid;

DOI:10.1021/jo01365a012

upstream raw materials:

2-acetamido-1-ethylbenzene

N-(2-ethyl-6-nitrophenyl)acetamide

nitric acid

acetic anhydride

Downstream raw materials:

2-Chlor-3-ethylnitrobenzol

2-bromo-1-ethyl-3-nitrobenzene

2-ethyl-6-nitro-benzonitrile

2-ethyl-6-nitrophenylazide