PEG4-tert-butyl acetate

Base Information

• Chemical Name: PEG4-tert-butyl acetate
• CAS No.: 169751-72-8
• Molecular Formula: C₁₄H₂₈O₇
• Molecular Weight: 308.372
• Mol file: 169751-72-8.mol

Synonyms:tert-butyl 14-hydroxy-3,6,9,12-tetraoxatetradecan-1-oate

Chemical Property of PEG4-tert-butyl acetate

Chemical Property:

• Boiling Point: 393.1±32.0 °C(Predicted)
• PKA: 14.36±0.10(Predicted)
• Density: 1.077±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility.: Soluble in Water, DMSO, DCM, DMF

Purity/Quality:

98%,99%, ^*data from raw suppliers

HO-PEG4-CH2COOtBu min.95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Hydroxy-PEG4-CH2CO2tBu is a PEG linker containing a hydroxyl group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Technology Process of PEG4-tert-butyl acetate

There total 7 articles about PEG4-tert-butyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

tert-butyl 1-phenyl-2,5,8,11,14-pentaoxahexadecan-16-oate → tert-butyl 14-hydroxy-3,6,9,12-tetraoxatetradecan-1-oate (169751-72-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 1.5h;

Reference yield: 72.7%

Tetraethylene glycol (112-60-7) + bromoacetic acid tert-butyl ester (5292-43-3) → tert-butyl 14-hydroxy-3,6,9,12-tetraoxatetradecan-1-oate (169751-72-8)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; mineral oil; at 0 - 20 ℃; for 23h; Inert atmosphere;

Reference yield:

Tetraethylene glycol (112-60-7) → tert-butyl 14-hydroxy-3,6,9,12-tetraoxatetradecan-1-oate (169751-72-8)

Guidance literature:

Multi-step reaction with 3 steps

1: NaH / dimethylformamide

2: NaH / dimethylformamide

3: TBAF

With tetrabutyl ammonium fluoride; sodium hydride; In N,N-dimethyl-formamide;

upstream raw materials:

[2-(2-{2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid tert-butyl ester

Tetraethylene glycol

bromoacetic acid tert-butyl ester

tetraethyleneglycol mono(tert-butyldimethylsilyl)ether

Downstream raw materials:

tert-butyl 2-[2-[2-[2-[2-(p-tolylsulfonyloxy)ethoxy]ethoxy]ethoxy]ethoxy]acetate

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