Technology Process of (1R,4'S,5'S)-1-(5'-tert-butyldiphenylsiloxymethyl)-(2',2'-dimethyl-5'-vinyl[1',3']dioxol-4'-yl)prop-2-en-1-ol
There total 1 articles about (1R,4'S,5'S)-1-(5'-tert-butyldiphenylsiloxymethyl)-(2',2'-dimethyl-5'-vinyl[1',3']dioxol-4'-yl)prop-2-en-1-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Methyltriphenylphosphonium bromide;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at 0 ℃;
for 1.5h;
C26H34O5Si;
In
tetrahydrofuran; hexane;
at 20 ℃;
for 48h;
DOI:10.1002/ejoc.201100062
- Guidance literature:
-
With
Umicore M2;
In
dichloromethane;
at 20 ℃;
for 70h;
Inert atmosphere;
Darkness;
DOI:10.1002/ejoc.201100062
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: Umicore M2 / dichloromethane / 70 h / 20 °C / Inert atmosphere; Darkness
2.1: dipyridinium dichromate / dichloromethane / 72 h / 20 °C / Molecular sieve
3.1: tetrahydrofuran / 0.5 h / -78 °C
3.2: 2 h / 20 °C
4.1: bromine / dichloromethane / 2 h / 20 °C
4.2: 0.33 h / 20 °C
4.3: 16 h / -78 - -30 °C
5.1: potassium carbonate / methanol / 12 h / 20 °C
6.1: N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid / 1,2-dichloro-ethane / -30 - 20 °C / Reflux
With
dipyridinium dichromate; bromine; potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1002/ejoc.201100062
