(S)-tert-butyl {2,2,2-trifluoro-1-[2-iodo-5-(trifluoromethyl)phenyl]ethyl}carbamate

Base Information

Chemical Name:(S)-tert-butyl {2,2,2-trifluoro-1-[2-iodo-5-(trifluoromethyl)phenyl]ethyl}carbamate
CAS No.:1421615-48-6
Molecular Formula:C₁₄H₁₄F₆INO₂
Molecular Weight:469.166
Hs Code.:

Synonyms:(S)-tert-butyl {2,2,2-trifluoro-1-[2-iodo-5-(trifluoromethyl)phenyl]ethyl}carbamate

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Chemical Property of (S)-tert-butyl {2,2,2-trifluoro-1-[2-iodo-5-(trifluoromethyl)phenyl]ethyl}carbamate

Chemical Property:

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Technology Process of (S)-tert-butyl {2,2,2-trifluoro-1-[2-iodo-5-(trifluoromethyl)phenyl]ethyl}carbamate

There total 5 articles about (S)-tert-butyl {2,2,2-trifluoro-1-[2-iodo-5-(trifluoromethyl)phenyl]ethyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1269822-85-6
(S)-2,2,2-trifluoro-1-(5-fluoro-2-iodophenyl)ethanamine

: 1421615-48-6
(S)-tert-butyl {2,2,2-trifluoro-1-[2-iodo-5-(trifluoromethyl)phenyl]ethyl}carbamate

Guidance literature:: With potassium carbonate; In 1,4-dioxane; at 20 ℃; Inert atmosphere;
DOI:10.1021/ol3035142

Reference yield:

: (R)-N-[2-iodo-5-(trifluoromethyl)benzylidene]-2-methylpropane-2-sulfinamide

: 1421615-48-6
(S)-tert-butyl {2,2,2-trifluoro-1-[2-iodo-5-(trifluoromethyl)phenyl]ethyl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutylammonium acetate / tetrahydrofuran / -20 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane; methanol / 0.33 h / 20 °C / Inert atmosphere

3: potassium carbonate / 1,4-dioxane / 20 °C / Inert atmosphere

With hydrogenchloride; tetrabutylammonium acetate; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1021/ol3035142

Reference yield:

: 875446-23-4
2-iodo-5-(trifluoromethyl)benzaldehyde

: 1421615-48-6
(S)-tert-butyl {2,2,2-trifluoro-1-[2-iodo-5-(trifluoromethyl)phenyl]ethyl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: titanium(IV) tetraethanolate / dichloromethane / 0.08 h / Inert atmosphere

1.2: 20 h / 20 °C / Inert atmosphere

2.1: tetrabutylammonium acetate / tetrahydrofuran / -20 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane; methanol / 0.33 h / 20 °C / Inert atmosphere

4.1: potassium carbonate / 1,4-dioxane / 20 °C / Inert atmosphere

With hydrogenchloride; titanium(IV) tetraethanolate; tetrabutylammonium acetate; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/ol3035142