2-IODO-5-(TRIFLUOROMETHYL)BENZALDEHYDE

Base Information

• Chemical Name: 2-IODO-5-(TRIFLUOROMETHYL)BENZALDEHYDE
• CAS No.: 875446-23-4
• Molecular Formula: C8H4F3IO
• Molecular Weight: 300.019
• Hs Code.: 2913000090
• Mol file: 875446-23-4.mol

Synonyms:2-iodo-4-nitro-5-trifluoromethyl-phenylamine;2-Iodo-4'-n-amyl-benzophenone;2-Iodo-4'-n-pentylbenzophenone;

Chemical Property of 2-IODO-5-(TRIFLUOROMETHYL)BENZALDEHYDE

Chemical Property:

• PSA: 17.07000
• LogP: 3.12250

Purity/Quality:

98%Min ^*data from raw suppliers

2-Iodo-5-(trifluoromethyl)benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-IODO-5-(TRIFLUOROMETHYL)BENZALDEHYDE

There total 4 articles about 2-IODO-5-(TRIFLUOROMETHYL)BENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

[2-iodo-5-(trifluoromethyl)phenyl]methanol (702641-05-2) → 2-iodo-5-(trifluoromethyl)benzaldehyde (875446-23-4)

Guidance literature:

With dipyridinium dichromate; silica gel; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b03577

Reference yield:

2-iodo-5-(trifluoromethyl)benzonitrile (868166-20-5) → 2-iodo-5-(trifluoromethyl)benzaldehyde (875446-23-4)

Guidance literature:

2-iodo-5-(trifluoromethyl)benzonitrile; With diisobutylaluminium hydride; In dichloromethane; at -78 - 0 ℃; for 1h;

With hydrogenchloride; In diethyl ether; dichloromethane; water; for 3h;

Reference yield:

2-iodo-4-(trifluoromethyl)aniline (163444-17-5) → 2-iodo-5-(trifluoromethyl)benzaldehyde (875446-23-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide / 4 h / Reflux

2.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C / Inert atmosphere

2.2: 4 h / 95 °C / Inert atmosphere

3.1: potassium hydroxide / water / 16 h / Reflux

4.1: Trimethyl borate; dimethylsulfide borane complex / tetrahydrofuran / 8 h / 20 °C / Inert atmosphere

5.1: silica gel; dipyridinium dichromate / dichloromethane / 6 h / 20 °C / Inert atmosphere

With hydrogenchloride; dipyridinium dichromate; Trimethyl borate; dimethylsulfide borane complex; silica gel; potassium hydroxide; sodium nitrite; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/acs.orglett.7b03577

upstream raw materials:

2-iodo-5-(trifluoromethyl)benzonitrile

2-amino-5-(trifluoromethyl)benzonitrile

[2-iodo-5-(trifluoromethyl)phenyl]methanol

2-iodo-4-(trifluoromethyl)aniline

Downstream raw materials:

(4S)-4-benzyl-3-{(2R,3S)-3-hydroxy-3-[2-iodo-5-(trifluoromethyl)phenyl]-2-methylpropanoyl}-1,3-oxazolidin-2-one

[2-iodo-5-(trifluoromethyl)phenyl]methanol

(S)-2,2,2-trifluoro-1-(5-fluoro-2-iodophenyl)ethanamine

(S)-tert-butyl {2,2,2-trifluoro-1-[2-iodo-5-(trifluoromethyl)phenyl]ethyl}carbamate

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