(+/-)-4β-<2-ethyl>octahydro-(1R)-1α-methyl-4-phenyl-3H-4aα-pyrido<1,2-c>-pyrimidin-3-one

Base Information

Chemical Name:(+/-)-4β-<2-ethyl>octahydro-(1R)-1α-methyl-4-phenyl-3H-4aα-pyrido<1,2-c>-pyrimidin-3-one
CAS No.:96997-17-0
Molecular Formula:C₂₃H₃₇N₃O
Molecular Weight:371.566
Hs Code.:

(+/-)-4β-<2-<bis(1-methylethyl)amino>ethyl>octahydro-(1R)-1α-methyl-4-phenyl-3H-4aα-pyrido<1,2-c>-pyrimidin-3-one

Synonyms:(+/-)-4β-<2-ethyl>octahydro-(1R)-1α-methyl-4-phenyl-3H-4aα-pyrido<1,2-c>-pyrimidin-3-one

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Chemical Property of (+/-)-4β-<2-ethyl>octahydro-(1R)-1α-methyl-4-phenyl-3H-4aα-pyrido<1,2-c>-pyrimidin-3-one

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Technology Process of (+/-)-4β-<2-ethyl>octahydro-(1R)-1α-methyl-4-phenyl-3H-4aα-pyrido<1,2-c>-pyrimidin-3-one

There total 4 articles about (+/-)-4β-<2-ethyl>octahydro-(1R)-1α-methyl-4-phenyl-3H-4aα-pyrido<1,2-c>-pyrimidin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 917-64-6
methyl magnesium iodide

: 91256-98-3
(4R,4aR)-4-(2-Diisopropylamino-ethyl)-4-phenyl-4,4a,5,6,7,8-hexahydro-pyrido[1,2-c]pyrimidin-3-one

: 96997-17-0
(+/-)-4β-<2-ethyl>octahydro-(1R)-1α-methyl-4-phenyl-3H-4aα-pyrido<1,2-c>-pyrimidin-3-one

Guidance literature:: With copper(I) chloride; In tetrahydrofuran; diethyl ether; for 1h;
DOI:10.1021/jm00147a029

Reference yield:

: 74427-45-5,74464-83-8,74464-84-9,3737-09-5
disopyramide

: 96997-17-0
(+/-)-4β-<2-ethyl>octahydro-(1R)-1α-methyl-4-phenyl-3H-4aα-pyrido<1,2-c>-pyrimidin-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / H₂SO₄, H₂ / 5percent PtO₂/C / H₂O / 4 h / 75 °C / 3102.9 Torr

2: 84 percent / diethyl ether / 12.5 h / 80 °C / Heating

3: 40 percent / Cu₂Cl₂ / tetrahydrofuran; diethyl ether / 1 h

With copper(I) chloride; sulfuric acid; hydrogen; PtO₂/C; In tetrahydrofuran; diethyl ether; water;
DOI:10.1021/jm00147a029

Reference yield:

: 107256-81-5
α-[2-[bis(1-methylethyl)amino]ethyl]-α-phenyl-2-piperidineacetamide

: 96997-17-0
(+/-)-4β-<2-ethyl>octahydro-(1R)-1α-methyl-4-phenyl-3H-4aα-pyrido<1,2-c>-pyrimidin-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / diethyl ether / 12.5 h / 80 °C / Heating

2: 40 percent / Cu₂Cl₂ / tetrahydrofuran; diethyl ether / 1 h

With copper(I) chloride; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jm00147a029