(S)-5-(2,6-difluorophenoxy)-3-(2-(5-fluoro-1H-indol-1-yl)acetamido)-4-oxopentanoic acid

Base Information

Chemical Name:(S)-5-(2,6-difluorophenoxy)-3-(2-(5-fluoro-1H-indol-1-yl)acetamido)-4-oxopentanoic acid
CAS No.:1351767-58-2
Molecular Formula:C₂₁H₁₇F₃N₂O₅
Molecular Weight:434.372
Hs Code.:

Synonyms:(S)-5-(2,6-difluorophenoxy)-3-(2-(5-fluoro-1H-indol-1-yl)acetamido)-4-oxopentanoic acid

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Chemical Property of (S)-5-(2,6-difluorophenoxy)-3-(2-(5-fluoro-1H-indol-1-yl)acetamido)-4-oxopentanoic acid

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Technology Process of (S)-5-(2,6-difluorophenoxy)-3-(2-(5-fluoro-1H-indol-1-yl)acetamido)-4-oxopentanoic acid

There total 6 articles about (S)-5-(2,6-difluorophenoxy)-3-(2-(5-fluoro-1H-indol-1-yl)acetamido)-4-oxopentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1351767-66-2
C₂₅H₂₅F₃N₂O₅

: 1351767-58-2
(S)-5-(2,6-difluorophenoxy)-3-(2-(5-fluoro-1H-indol-1-yl)acetamido)-4-oxopentanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃;

Reference yield:

: 796071-90-4
2-(5-fluoro-1H-indol-1-yl)acetic acid

: 1351767-58-2
(S)-5-(2,6-difluorophenoxy)-3-(2-(5-fluoro-1H-indol-1-yl)acetamido)-4-oxopentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

2: Dess-Martin periodane / dichloromethane / 1.67 h / 0 °C

3: trifluoroacetic acid / dichloromethane / 0 °C

With benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 153088-76-7
(S)-3-benzyloxycarbonylamino-5-bromo-4-oxo-pentanoic acid tert-butyl ester

: 1351767-58-2
(S)-5-(2,6-difluorophenoxy)-3-(2-(5-fluoro-1H-indol-1-yl)acetamido)-4-oxopentanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: potassium fluoride / N,N-dimethyl-formamide / 1 h / 20 °C

2: sodium tetrahydroborate / ethanol / 0.5 h / 0 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

5: Dess-Martin periodane / dichloromethane / 1.67 h / 0 °C

6: trifluoroacetic acid / dichloromethane / 0 °C

With potassium fluoride; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 1: modified Finkel-stein reaction;