(2S,4S,6S)-2-{(S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-hydroxy-hept-6-enyl}-6-[(S)-4-(tert-butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2-methoxy-3,3-dimethyl-tetrahydro-pyran-4-ol

Base Information

• Chemical Name: (2S,4S,6S)-2-{(S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-hydroxy-hept-6-enyl}-6-[(S)-4-(tert-butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2-methoxy-3,3-dimethyl-tetrahydro-pyran-4-ol
• CAS No.: 121353-17-1
• Molecular Formula: C₅₅H₇₈O₈Si₂
• Molecular Weight: 923.391

Synonyms:(2S,4S,6S)-2-{(S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-hydroxy-hept-6-enyl}-6-[(S)-4-(tert-butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2-methoxy-3,3-dimethyl-tetrahydro-pyran-4-ol

Chemical Property of (2S,4S,6S)-2-{(S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-hydroxy-hept-6-enyl}-6-[(S)-4-(tert-butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2-methoxy-3,3-dimethyl-tetrahydro-pyran-4-ol

Chemical Property:

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Technology Process of (2S,4S,6S)-2-{(S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-hydroxy-hept-6-enyl}-6-[(S)-4-(tert-butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2-methoxy-3,3-dimethyl-tetrahydro-pyran-4-ol

There total 1 articles about (2S,4S,6S)-2-{(S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-hydroxy-hept-6-enyl}-6-[(S)-4-(tert-butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2-methoxy-3,3-dimethyl-tetrahydro-pyran-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

7-[2-(tert-Butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-{(4S,6R)-6-[(S)-4-(tert-butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-5-hydroxy-2-methyl-dec-9-en-3-one (121353-16-0,121422-56-8) + trimethyl orthoformate (149-73-5) → (2S,4S,6S)-2-{(S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-hydroxy-hept-6-enyl}-6-[(S)-4-(tert-butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2-methoxy-3,3-dimethyl-tetrahydro-pyran-4-ol (121353-17-1)

Guidance literature:

With pyridinium p-toluenesulfonate; In methanol; for 2.5h; Ambient temperature;

DOI:10.1021/jo00273a009

Reference yield:

(2S,4S,6S)-2-{(S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-hydroxy-hept-6-enyl}-6-[(S)-4-(tert-butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2-methoxy-3,3-dimethyl-tetrahydro-pyran-4-ol (121353-17-1) → Acetic acid (2S,4S,6R)-2-{(2S,6R)-4-[2-(tert-butyl-diphenyl-silanyloxy)-eth-(Z)-ylidene]-6-formyl-tetrahydro-pyran-2-ylmethyl}-6-[(S)-4-(tert-butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2-methoxy-3,3-dimethyl-tetrahydro-pyran-4-yl ester (121353-19-3,121422-58-0)

Guidance literature:

Multi-step reaction with 2 steps

2: (COCl)2 / dimethylsulfoxide; CH₂Cl₂ / 0.5 h / -78 °C

With oxalyl dichloride; In dichloromethane; dimethyl sulfoxide;

DOI:10.1021/jo00273a009

Reference yield:

(2S,4S,6S)-2-{(S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-hydroxy-hept-6-enyl}-6-[(S)-4-(tert-butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2-methoxy-3,3-dimethyl-tetrahydro-pyran-4-ol (121353-17-1) → Acetic acid (2S,4S,6R)-2-{(2S,6S)-4-[2-(tert-butyl-diphenyl-silanyloxy)-eth-(Z)-ylidene]-6-formyl-tetrahydro-pyran-2-ylmethyl}-6-[(S)-4-(tert-butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2-methoxy-3,3-dimethyl-tetrahydro-pyran-4-yl ester (121353-19-3,121422-58-0)

Guidance literature:

Multi-step reaction with 2 steps

2: (COCl)2 / dimethylsulfoxide; CH₂Cl₂ / 0.5 h / -78 °C

With oxalyl dichloride; In dichloromethane; dimethyl sulfoxide;

DOI:10.1021/jo00273a009

upstream raw materials:

7-[2-(tert-Butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-{(4S,6R)-6-[(S)-4-(tert-butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-5-hydroxy-2-methyl-dec-9-en-3-one

trimethyl orthoformate

Downstream raw materials:

Acetic acid (2S,4S,6R)-2-{(S)-4-[2-(tert-butyl-diphenyl-silanyloxy)-eth-(Z)-ylidene]-6-hydroxymethyl-tetrahydro-pyran-2-ylmethyl}-6-[(S)-4-(tert-butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2-methoxy-3,3-dimethyl-tetrahydro-pyran-4-yl ester

Acetic acid (2S,4S,6R)-2-{(2S,6R)-4-[2-(tert-butyl-diphenyl-silanyloxy)-eth-(Z)-ylidene]-6-formyl-tetrahydro-pyran-2-ylmethyl}-6-[(S)-4-(tert-butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2-methoxy-3,3-dimethyl-tetrahydro-pyran-4-yl ester

Acetic acid (2S,4S,6R)-2-{(2S,6S)-4-[2-(tert-butyl-diphenyl-silanyloxy)-eth-(Z)-ylidene]-6-formyl-tetrahydro-pyran-2-ylmethyl}-6-[(S)-4-(tert-butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2-methoxy-3,3-dimethyl-tetrahydro-pyran-4-yl ester

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