(6-{2-[3-(4-fluorophenyl)-5-(4-hydroxymethylbenzylcarbamoyl)-1-isopropyl-4-phenyl-1H-pyrrol-2-yl]ethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)acetic acid tert-butyl ester

Base Information

Chemical Name:(6-{2-[3-(4-fluorophenyl)-5-(4-hydroxymethylbenzylcarbamoyl)-1-isopropyl-4-phenyl-1H-pyrrol-2-yl]ethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)acetic acid tert-butyl ester
CAS No.:855249-17-1
Molecular Formula:C₄₂H₅₁FN₂O₆
Molecular Weight:698.875
Hs Code.:

(6-{2-[3-(4-fluorophenyl)-5-(4-hydroxymethylbenzylcarbamoyl)-1-isopropyl-4-phenyl-1H-pyrrol-2-yl]ethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)acetic acid tert-butyl ester

Synonyms:(6-{2-[3-(4-fluorophenyl)-5-(4-hydroxymethylbenzylcarbamoyl)-1-isopropyl-4-phenyl-1H-pyrrol-2-yl]ethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)acetic acid tert-butyl ester

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Chemical Property of (6-{2-[3-(4-fluorophenyl)-5-(4-hydroxymethylbenzylcarbamoyl)-1-isopropyl-4-phenyl-1H-pyrrol-2-yl]ethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)acetic acid tert-butyl ester

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Technology Process of (6-{2-[3-(4-fluorophenyl)-5-(4-hydroxymethylbenzylcarbamoyl)-1-isopropyl-4-phenyl-1H-pyrrol-2-yl]ethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)acetic acid tert-butyl ester

There total 1 articles about (6-{2-[3-(4-fluorophenyl)-5-(4-hydroxymethylbenzylcarbamoyl)-1-isopropyl-4-phenyl-1H-pyrrol-2-yl]ethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 855249-16-0
(6-{2-[3-(4-fluorophenyl)-5-(4-hydroxymethylbenzylcarbamoyl)-1-isopropyl-4-phenyl-1H-pyrrol-2-yl]vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)acetic acid tert-butyl ester

: 855249-17-1
(6-{2-[3-(4-fluorophenyl)-5-(4-hydroxymethylbenzylcarbamoyl)-1-isopropyl-4-phenyl-1H-pyrrol-2-yl]ethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)acetic acid tert-butyl ester

Guidance literature:: With hydrogen; N-butylamine; palladium 10% on activated carbon; In ethanol; for 6h;

Reference yield: 99.0%

: 855249-17-1
(6-{2-[3-(4-fluorophenyl)-5-(4-hydroxymethylbenzylcarbamoyl)-1-isopropyl-4-phenyl-1H-pyrrol-2-yl]ethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)acetic acid tert-butyl ester

: 124-63-0
methanesulfonyl chloride

: 855249-20-6
(6-{2-[3-(4-fluorophenyl)-1-isopropyl-5-(4-methanesulfonyloxymethylbenzylcarbamoyl)-4-phenyl-1H-pyrrol-2-yl]ethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)acetic acid tert-butyl ester

Guidance literature:: (6-{2-[3-(4-fluorophenyl)-5-(4-hydroxymethylbenzylcarbamoyl)-1-isopropyl-4-phenyl-1H-pyrrol-2-yl]ethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)acetic acid tert-butyl ester; methanesulfonyl chloride; With triethylamine; In dichloromethane; at 0 - 25 ℃; for 1h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield: 57.0%

: 855249-17-1
(6-{2-[3-(4-fluorophenyl)-5-(4-hydroxymethylbenzylcarbamoyl)-1-isopropyl-4-phenyl-1H-pyrrol-2-yl]ethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)acetic acid tert-butyl ester

: 7-[3-(4-fluorophenyl)-5-(4-hydroxymethylbenzylcarbamoyl)-1-isopropyl-4-phenyl-1H-pyrrol-2-yl]-3,5-dihydroxyheptanoic acid tert-butyl ester

Guidance literature:: (6-{2-[3-(4-fluorophenyl)-5-(4-hydroxymethylbenzylcarbamoyl)-1-isopropyl-4-phenyl-1H-pyrrol-2-yl]ethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)acetic acid tert-butyl ester; With water; hydrogenchloride; In methanol; at 20 ℃; for 12h;

With sodium hydrogencarbonate; In methanol; dichloromethane; water;