2'-DEOXY-8-(9H-FLUOREN-2-YLAMINO)-GUANOSINE

Base Information

• Chemical Name: 2'-DEOXY-8-(9H-FLUOREN-2-YLAMINO)-GUANOSINE
• CAS No.: 73051-69-1
• Molecular Formula: C23H22 N6 O4
• Molecular Weight: 446.465
• Mol file: 73051-69-1.mol

Synonyms:2'-Deoxy-8-(9H-fluoren-2-ylamino)guanosine;N-(2'-Deoxyguanosin-8-yl)-2-aminofluorene; N-(Deoxyguanosin-8-yl)-2-aminofluorene;N-(Deoxyguanosine-C8-yl)-2-aminofluorene

Chemical Property of 2'-DEOXY-8-(9H-FLUOREN-2-YLAMINO)-GUANOSINE

Chemical Property:

• Boiling Point: 822.1oC at 760 mmHg
• Flash Point: 451oC
• PSA: 151.31000
• Density: 1.74g/cm3
• LogP: 2.17860

Purity/Quality:

97% ^*data from raw suppliers

2’-Deoxy-8-(9H-fluoren-2-ylamino)-guanosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A C8-deoxyguanosine adduct of the dietary mutagen IQ

Technology Process of 2'-DEOXY-8-(9H-FLUOREN-2-YLAMINO)-GUANOSINE

There total 39 articles about 2'-DEOXY-8-(9H-FLUOREN-2-YLAMINO)-GUANOSINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-(benzoyl)-N-(deoxyguanosin-8-yl)-2-aminofluorene (411240-49-8) → 2-fluoren (73051-69-1)

Guidance literature:

With methanol; sodium carbonate; at 20 ℃; for 8h;

DOI:10.1055/s-2001-18718

Reference yield: 80.0%

N-(deoxyguanosin-8-yl)-2-acetamidofluorene (37819-60-6) → N-(deoxyguanosin-8-yl)-2-aminofluorene (73051-69-1)

Guidance literature:

With sodium hydroxide; In ethanol; at 100 ℃; for 0.5h;

DOI:10.1021/jm00148a014

Reference yield: 77.0%

8-(9H-fluoren-2-ylamino)-N9-[3',5'-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)-β-D-2'-deoxyribofuranosyl]guanine (156593-80-5) → 2-fluoren (73051-69-1)

Guidance literature:

With pyridine hydrogenfluoride; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1021/ja0487022

upstream raw materials:

fluorene

O-Acetyl-N-(2-fluorenyl)hydroxylamin

2'-Deoxyguanosine

2-azido-9H-fluorene