Multi-step reaction with 11 steps
1.1: hydrogenchloride / 3 h / Reflux
2.1: triethylamine / tetrahydrofuran / 2.17 h / 10 - 20 °C / Cooling with ice
3.1: 2,6-dimethylpyridine; trifluoromethylsulfonic anhydride / acetonitrile / 0.67 h / -36 - -30 °C
3.2: 48 h / -32 - 4 °C
4.1: hydrogenchloride / methanol / 72 h / Reflux
5.1: potassium carbonate / ethyl acetate; water
6.1: triethylamine / acetonitrile / 0.33 h / 2 - 5 °C / Cooling with ice
6.2: 10 h / 20 °C
7.1: water; lithium hydroxide / tetrahydrofuran / 2.17 h / 2 - 4.9 °C
8.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.25 h / 0 °C / Cooling with ice
8.2: 1.5 h / 0 - 20 °C
9.1: palladium 10% on activated carbon; hydrogen / water; methanol / 0.92 h / 20 °C
10.1: sulfur trioxide pyridine complex / pyridine / 20 °C
10.2: 0.25 h
11.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
With
2,6-dimethylpyridine; hydrogenchloride; trifluoromethylsulfonic anhydride; palladium 10% on activated carbon; water; hydrogen; sulfur trioxide pyridine complex; potassium carbonate; triethylamine; trifluoroacetic acid; lithium hydroxide; isobutyl chloroformate;
In
tetrahydrofuran; pyridine; methanol; dichloromethane; water; ethyl acetate; acetonitrile;
