7087-68-5Relevant academic research and scientific papers
Preparation method of diisopropylethylamine
-
Paragraph 0024-0035, (2020/08/18)
The invention provides a preparation method of diisopropylethylamine, and belongs to the technical field of organic synthesis. According to the preparation method of the diisopropylethylamine, diisopropylamine is used as a raw material, the diisopropylamine and ethanol are subjected to a hydrogen borrowing reaction under the catalytic action of triphenylphosphine ruthenium acetate or a mixture ofthe triphenylphosphine ruthenium acetate and ferric oxide in a certain proportion, and the yield is high. Compared with the prior art, the method has the advantages of high atom economy, cleanness, zero pollution, high efficiency and low cost, and the only by-product in the reaction is water; the catalyst is cheap and easily available, the use of the mixed catalyst effectively reduces the use amount of a noble metal organic catalyst, the synergistic effect obtains high yield, and the method is also suitable for other large-space rental substrates.
Electroactivated alkylation of amines with alcohols: Via both direct and indirect borrowing hydrogen mechanisms
Appiagyei, Benjamin,Bhatia, Souful,Keeney, Gabriela L.,Dolmetsch, Troy,Jackson, James E.
supporting information, p. 860 - 869 (2020/02/21)
A green, efficient N-alkylation of amines with simple alcohols has been achieved in aqueous solution via an electrochemical version of the so-called "borrowing hydrogen methodology". Catalyzed by Ru on activated carbon cloth (Ru/ACC), the reaction works well with methanol, and with primary and secondary alcohols. Alkylation can be accomplished by either of two different electrocatalytic processes: (1) in an undivided cell, alcohol (present in excess) is oxidized at the Ru/ACC anode; the aldehyde or ketone product condenses with the amine; and the resulting imine is reduced at an ACC cathode, combining with protons released by the oxidation. This process consumes stoichiometric quantities of current. (2) In a membrane-divided cell, the current-activated Ru/ACC cathode effects direct C-H activation of the alcohol; the resulting carbonyl species, either free or still surface-adsorbed, condenses with amine to form imine and is reduced as in (1). These alcohol activation processes can alkylate primary and secondary aliphatic amines, as well as ammonia itself at 25-70 °C and ambient pressure.
Method for preventing catalyst ZnCl2 from caking in diisopropylethylamine production
-
Paragraph 0036-0072, (2020/08/09)
The invention discloses a method for preventing catalyst ZnCl2 from caking in diisopropylethylamine production, which takes diisopropylamine and chloroethane as raw materials, and comprises the following steps: adding ZnCl2 serving as a catalyst into the raw materials, and adding an anti-caking agent to form a reaction system; reacting the reaction system for 5-10 hours at the reaction temperatureof 150-190 DEG C and under the reaction pressure of 1.5-2.2 MPa; and carrying out alkali dissolution on the obtained reaction liquid, separating out a water phase, and carrying out atmospheric distillation on an organic phase to obtain the N,N-diisopropylethylamine serving as a product. According to the method disclosed by the invention, the catalyst is prevented from caking in the reaction, andthe product yield is high.
Mild N-Alkylation of Amines with Alcohols Catalyzed by the Acetate Ru(OAc)2(CO)(DiPPF) Complex
Figliolia, Rosario,Baldino, Salvatore,Nedden, Hans G.,Zanotti-Gerosa, Antonio,Baratta, Walter
supporting information, p. 14416 - 14419 (2017/10/07)
The acetate complex Ru(OAc)2(DiPPF) (2) obtained from Ru(OAc)2(PPh3)2 (1) and 1,1′-bis(diisopropylphosphino)ferrocene (DiPPF) reacts cleanly with formaldehyde affording Ru(OAc)2(CO)(DiPPF) (3) in high yield. The monocarbonyl complex 3 (0.4-2 mol %) efficiently catalyzes the N-alkylation of primary and secondary alkyl and aromatic amines using primary alcohols ROH (R=Et, nPr, nBu, PhCH2) under mild reaction conditions (30–100 °C) with an alcohol/amine molar ratio of 10-100. Formation of the monohydride RuH(OAc)(CO)(DiPPF) (4) has been observed by reaction of 3 with iPrOH in the presence of NEt3 at RT through an equilibrium reaction.
METHOD FOR PRODUCING N-ETHYL-DIISOPROPYLAMINE
-
Paragraph 0078-0079, (2017/01/26)
A process for preparing N-ethyldiisopropylamine by reacting acetaldehyde with diisopropylamine and hydrogen at elevated temperature and under pressure in the presence of a heterogeneous hydrogenation catalyst, the catalyst being a supported transition metal catalyst comprising Pd and/or Pt as catalytically active metal, wherein the diisopropylamine used has a purity of 58% to 94% by weight and impurities as follows: 3% to 20% by weight of water, 3% to 20% by weight of isopropanol, 0% to 2% by weight of others.
Method for synthesis of N,N-diisopropyl ethylamine
-
Paragraph 0018-0038, (2017/04/18)
The invention discloses a method for synthesis of N,N-diisopropyl ethylamine; with diisopropylamine as a reaction raw material, a quaternary ammonium salt as an ethylization reagent and alcohol as a solvent, and under a condition of the presence of an acid binding agent, N,N-diisopropyl ethylamine is synthesized; the molar ratio of the diisopropylamine to the quaternary ammonium salt is 1 to (1-2), and a refluxing reaction is performed for 3-7 hours; the obtained reaction product is postprocessed to obtain high-purity N,N-diisopropyl ethylamine. The DIPEA synthesized by the method has the advantages of simple operation, relatively high yield, simple postprocessing and the like.
GIP analog and hybrid polypeptides with selectable properties
-
, (2016/01/20)
The present invention relates generally to novel GIP analogs and GIP hybrid polypeptides with selectable properties, useful as agents for the treatment and prevention of metabolic diseases and disorders, for example those which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, positive inotropic effects, reduction of catabolic effects, slowing of gastric emptying. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, critical care, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.
CONTRAST ENHANCEMENT AGENTS AND METHOD OF USE THEREOF
-
Page/Page column, (2014/04/03)
A contrast agent composition and a method of diagnostic imaging are provided. The composition comprises a pharmaceutically acceptable carrier and a metal-complex comprising a ligand having structure (XXX): wherein R1, R2, R3, R7, R8, R′1, R′2, R′3, R7′ and R8′ are selected form hydrogen, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group; R4, R′4 are selected from a hydrogen, a hydroxyl, a protected hydroxyl group, a protected C1-C3 hydroxyalkyl group, a C1-C3 alkyl group; n is an integer between 0 and 4; R5, R′5 are selected from a hydrogen, a protecting group comprising C1-C30 aliphatic radicals, C3-C30 cycloaliphatic radicals, C2-C30 aromatic radicals, m is an integer between 1 and 10; at least one of R7 and R′7 is acidic groups or protected acidic groups; Y comprises a protein or peptide moiety, a particle, a micelle, a liposome, an organic molecule, oligomer, polymer or a hydrophilic moiety.
QUINAZOLINE-2,4-DIONE DERIVATIVES
-
, (2014/06/25)
The invention relates to antibacterial compounds of formula (I), wherein R1 is H, halogen, (C1-C3)alkyl or (C1-C3)alkoxy; R2 is H, halogen, (C1-C3)alkyl, (C1-C3)alkoxy or pyrrolidin-1-yl; R3 is H, halogen, (C1-C3)alkyl, (C1-C3)alkoxy, vinyl or 2-methoxycarbonyvinyl or R2 and R3 together with the two carbon atoms which bear them form a phenyl ring; R4 is H, halogen, (C1-C3)alkyl or (C1-C3)alkoxy; and R5 is H, (C1-C3)alkyl or cyclopropyl, or R4 and R5 form together a —CH2CH2CH2— group; A is the divalent group —CH2—, —CH2CH2—, #—CH(OH)CH2—*, #—CH2N(R6)—* and —CH2NHCH2—, wherein # indicates the point of attachment to the optionally substituted (quinazoline-2,4-dione-3-yl)methyl residue and * represents the point of attachment to the substituted (oxazolidinon-4-yl)methyl residue; R6 is H or acetyl; Y is CH or N; and Q is O or S; and salts of such compounds.
OLIGONUCLEOTIDE WITH PROTECTED BASE
-
Page/Page column, (2013/10/22)
The present invention provides a protected nucleotide for elongation, which can be purified efficiently and in a high yield by a liquid-liquid extraction operation, and can achieve an oligonucleotide production method by a phosphoramidite method. It has been found that the above-mentioned problem can be solved by a particular oligonucleotide comprising a protected base and/or particular oligonucleotide protected by a branched chain-containing aromatic group at 3′-position.
