methyl 2-({4-[(Z)-2-fluoro-2-(5-methyl-1H-pyrazol-3-yl)vinyl]phenyl}sulphanyl)-2-methyl-propanoate

Base Information

Chemical Name:methyl 2-({4-[(Z)-2-fluoro-2-(5-methyl-1H-pyrazol-3-yl)vinyl]phenyl}sulphanyl)-2-methyl-propanoate
CAS No.:1418297-19-4
Molecular Formula:C₁₇H₁₉FN₂O₂S
Molecular Weight:334.414
Hs Code.:

Synonyms:methyl 2-({4-[(Z)-2-fluoro-2-(5-methyl-1H-pyrazol-3-yl)vinyl]phenyl}sulphanyl)-2-methyl-propanoate

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Chemical Property of methyl 2-({4-[(Z)-2-fluoro-2-(5-methyl-1H-pyrazol-3-yl)vinyl]phenyl}sulphanyl)-2-methyl-propanoate

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Technology Process of methyl 2-({4-[(Z)-2-fluoro-2-(5-methyl-1H-pyrazol-3-yl)vinyl]phenyl}sulphanyl)-2-methyl-propanoate

There total 9 articles about methyl 2-({4-[(Z)-2-fluoro-2-(5-methyl-1H-pyrazol-3-yl)vinyl]phenyl}sulphanyl)-2-methyl-propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1418297-21-8
2-({4-[(Z)-2-fluoro-2-(5-methyl-1H-pyrazol-3-yl)vinyl]phenyl}sulphanyl)-2-methylpropanoic acid

: 1418297-19-4
methyl 2-({4-[(Z)-2-fluoro-2-(5-methyl-1H-pyrazol-3-yl)vinyl]phenyl}sulphanyl)-2-methyl-propanoate

Guidance literature:: With thionyl chloride; In methanol; at 0 - 20 ℃;

Reference yield:

: 4027-57-0
ethyl 5-methyl-1H-pyrazole-3-carboxylate

: 1418297-19-4
methyl 2-({4-[(Z)-2-fluoro-2-(5-methyl-1H-pyrazol-3-yl)vinyl]phenyl}sulphanyl)-2-methyl-propanoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 16 h / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

4.1: N,N-dimethyl-formamide / 1 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

6.1: lithium diisopropyl amide / tetrahydrofuran; toluene; hexane / 0.5 h / -78 °C

6.2: 16 h / -78 - 20 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

8.1: hydrogenchloride / 1,4-dioxane / 20 °C

9.1: thionyl chloride / methanol / 0 - 20 °C

With hydrogenchloride; thionyl chloride; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1418296-88-4
ethyl 5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-3-carboxylate

: 1418297-19-4
methyl 2-({4-[(Z)-2-fluoro-2-(5-methyl-1H-pyrazol-3-yl)vinyl]phenyl}sulphanyl)-2-methyl-propanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

1.2: 0 - 20 °C

2.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

3.1: N,N-dimethyl-formamide / 1 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

5.1: lithium diisopropyl amide / tetrahydrofuran; toluene; hexane / 0.5 h / -78 °C

5.2: 16 h / -78 - 20 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

7.1: hydrogenchloride / 1,4-dioxane / 20 °C

8.1: thionyl chloride / methanol / 0 - 20 °C

With hydrogenchloride; thionyl chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;