2-({4-[(Z)-2-fluoro-2-(5-methyl-1H-pyrazol-3-yl)vinyl]phenyl}sulphanyl)-2-methylpropanoic acid

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Chemical Name:2-({4-[(Z)-2-fluoro-2-(5-methyl-1H-pyrazol-3-yl)vinyl]phenyl}sulphanyl)-2-methylpropanoic acid
CAS No.:1418297-21-8
Molecular Formula:C₁₆H₁₇FN₂O₂S
Molecular Weight:320.388
Hs Code.:

Synonyms:2-({4-[(Z)-2-fluoro-2-(5-methyl-1H-pyrazol-3-yl)vinyl]phenyl}sulphanyl)-2-methylpropanoic acid

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Chemical Property of 2-({4-[(Z)-2-fluoro-2-(5-methyl-1H-pyrazol-3-yl)vinyl]phenyl}sulphanyl)-2-methylpropanoic acid

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Technology Process of 2-({4-[(Z)-2-fluoro-2-(5-methyl-1H-pyrazol-3-yl)vinyl]phenyl}sulphanyl)-2-methylpropanoic acid

There total 7 articles about 2-({4-[(Z)-2-fluoro-2-(5-methyl-1H-pyrazol-3-yl)vinyl]phenyl}sulphanyl)-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1418297-20-7
tert-butyl 2-[(4-{(Z)-2-fluoro-2-[5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl]vinyl}phenyl)sulphanyl]-2-methylpropanoate

: 1418297-21-8
2-({4-[(Z)-2-fluoro-2-(5-methyl-1H-pyrazol-3-yl)vinyl]phenyl}sulphanyl)-2-methylpropanoic acid

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

Reference yield:

: 4027-57-0
ethyl 5-methyl-1H-pyrazole-3-carboxylate

: 1418297-21-8
2-({4-[(Z)-2-fluoro-2-(5-methyl-1H-pyrazol-3-yl)vinyl]phenyl}sulphanyl)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 16 h / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

4.1: N,N-dimethyl-formamide / 1 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

6.1: lithium diisopropyl amide / tetrahydrofuran; toluene; hexane / 0.5 h / -78 °C

6.2: 16 h / -78 - 20 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

8.1: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1418296-88-4
ethyl 5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-3-carboxylate

: 1418297-21-8
2-({4-[(Z)-2-fluoro-2-(5-methyl-1H-pyrazol-3-yl)vinyl]phenyl}sulphanyl)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

1.2: 0 - 20 °C

2.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

3.1: N,N-dimethyl-formamide / 1 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

5.1: lithium diisopropyl amide / tetrahydrofuran; toluene; hexane / 0.5 h / -78 °C

5.2: 16 h / -78 - 20 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

7.1: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;