2-(3-Trifluoromethyl-phenyl)-tetrahydro-pyrrolo[3,4-c]pyrrole-1,3-dione; hydrochloride

Base Information

Chemical Name:2-(3-Trifluoromethyl-phenyl)-tetrahydro-pyrrolo[3,4-c]pyrrole-1,3-dione; hydrochloride
CAS No.:86732-17-4
Molecular Formula:C₁₃H₁₁F₃N₂O₂*ClH
Molecular Weight:320.699
Hs Code.:

Synonyms:2-(3-Trifluoromethyl-phenyl)-tetrahydro-pyrrolo[3,4-c]pyrrole-1,3-dione; hydrochloride

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Chemical Property of 2-(3-Trifluoromethyl-phenyl)-tetrahydro-pyrrolo[3,4-c]pyrrole-1,3-dione; hydrochloride

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Technology Process of 2-(3-Trifluoromethyl-phenyl)-tetrahydro-pyrrolo[3,4-c]pyrrole-1,3-dione; hydrochloride

There total 4 articles about 2-(3-Trifluoromethyl-phenyl)-tetrahydro-pyrrolo[3,4-c]pyrrole-1,3-dione; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 86732-07-2
5-Benzyl-2-(3-trifluoromethyl-phenyl)-5H-pyrrolo[3,4-c]pyrrole-1,3-dione

: 86732-17-4
2-(3-Trifluoromethyl-phenyl)-tetrahydro-pyrrolo[3,4-c]pyrrole-1,3-dione; hydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In acetic acid; at 55 ℃; for 18h; under 2585.7 Torr;

Reference yield:

: 86731-90-0
1-benzyl-pyrrole-3,4-dicarboxylic acid

: 86732-17-4
2-(3-Trifluoromethyl-phenyl)-tetrahydro-pyrrolo[3,4-c]pyrrole-1,3-dione; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / dicyclohexylcarbodiimide / tetrahydrofuran / Heating; overnight

2: 76 percent / tetrahydrofuran

3: 83 percent / 1.) SOCl₂ / 1.) benzene, reflux, 1.5 h; 2.) 180 deg C

4: 57 percent / H₂; HCl / 10percent Pd/C / acetic acid / 18 h / 55 °C / 2585.7 Torr

With hydrogenchloride; thionyl chloride; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; acetic acid;

Reference yield:

: 86731-92-2
1-benzyl-1H-pyrrole-3,4-dicarboxylic anhydride

: 86732-17-4
2-(3-Trifluoromethyl-phenyl)-tetrahydro-pyrrolo[3,4-c]pyrrole-1,3-dione; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / tetrahydrofuran

2: 83 percent / 1.) SOCl₂ / 1.) benzene, reflux, 1.5 h; 2.) 180 deg C

3: 57 percent / H₂; HCl / 10percent Pd/C / acetic acid / 18 h / 55 °C / 2585.7 Torr

With hydrogenchloride; thionyl chloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; acetic acid;