(S)-N-[(S)-1-phenylethyl]-N-(3-methoxybenzyl)-2-acetyloxy-2-phenylethanamide

Base Information

• Chemical Name: (S)-N-[(S)-1-phenylethyl]-N-(3-methoxybenzyl)-2-acetyloxy-2-phenylethanamide
• CAS No.: 620598-76-7
• Molecular Formula: C₂₆H₂₇NO₄
• Molecular Weight: 417.505
• Mol file: 620598-76-7.mol

Synonyms:(S)-N-[(S)-1-phenylethyl]-N-(3-methoxybenzyl)-2-acetyloxy-2-phenylethanamide

Chemical Property of (S)-N-[(S)-1-phenylethyl]-N-(3-methoxybenzyl)-2-acetyloxy-2-phenylethanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-[(S)-1-phenylethyl]-N-(3-methoxybenzyl)-2-acetyloxy-2-phenylethanamide

There total 2 articles about (S)-N-[(S)-1-phenylethyl]-N-(3-methoxybenzyl)-2-acetyloxy-2-phenylethanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-chloro-2-oxo-1-phenylethyl acetate (51019-44-4) + (S)-N-(3-methoxybenzyl)-1-phenylethylamine (620598-71-2) → (S)-N-[(S)-1-phenylethyl]-N-(3-methoxybenzyl)-2-acetyloxy-2-phenylethanamide (620598-76-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1016/S0040-4020(03)01236-5

Reference yield:

3-methoxy-benzaldehyde (591-31-1) → (S)-N-[(S)-1-phenylethyl]-N-(3-methoxybenzyl)-2-acetyloxy-2-phenylethanamide (620598-76-7)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / 0.25 h / 20 °C

2: 13.0 g / NaBH₄ / methanol / 1 h / 20 °C

3: N,N-diisopropylethylamine / CH₂Cl₂ / 4 h / 20 °C

With sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;

DOI:10.1016/S0040-4020(03)01236-5

Reference yield: 20.0%

(S)-N-[(S)-1-phenylethyl]-N-(3-methoxybenzyl)-2-acetyloxy-2-phenylethanamide (620598-76-7) → (4S)-N-((S)-1-phenylethyl)-7-methoxy-4-phenyl-1,4-dihydroisoquinolin-3-one

Guidance literature:

With sulfuric acid; In dichloromethane; at -15 ℃; for 4h;

DOI:10.1016/S0040-4020(03)01236-5

upstream raw materials:

(S)-2-chloro-2-oxo-1-phenylethyl acetate

(S)-N-(3-methoxybenzyl)-1-phenylethylamine

3-methoxy-benzaldehyde