1-benzyl-3,3-difluoro-4-((phenylselanyl)methyl)pyrrolidin-2-one

Base Information

• Chemical Name: 1-benzyl-3,3-difluoro-4-((phenylselanyl)methyl)pyrrolidin-2-one
• CAS No.: 198547-54-5
• Molecular Formula: C₁₈H₁₇F₂NOSe
• Molecular Weight: 380.296
• Mol file: 198547-54-5.mol

Synonyms:1-benzyl-3,3-difluoro-4-((phenylselanyl)methyl)pyrrolidin-2-one

Chemical Property of 1-benzyl-3,3-difluoro-4-((phenylselanyl)methyl)pyrrolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-3,3-difluoro-4-((phenylselanyl)methyl)pyrrolidin-2-one

There total 3 articles about 1-benzyl-3,3-difluoro-4-((phenylselanyl)methyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

diphenyl diselenide (1666-13-3) + N-allyl-N-benzyl-2-bromo-2,2-difluoroacetamide (198547-63-6) → N-Allyl-N-benzyl-2,2-difluoro-2-phenylselanyl-acetamide + 1-benzyl-3,3-difluoro-4-((phenylselanyl)methyl)pyrrolidin-2-one (198547-54-5)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; ethanol; at 0 ℃; for 3h;

DOI:10.1016/S0040-4039(97)10073-9

Reference yield: 61.0%

diphenyl diselenide (1666-13-3) + N-allyl-N-benzyl-2-bromo-2,2-difluoroacetamide (198547-63-6) → 1-benzyl-3,3-difluoro-4-((phenylselanyl)methyl)pyrrolidin-2-one (198547-54-5)

Guidance literature:

With dipotassium hydrogenphosphate; In dimethyl sulfoxide; at 20 ℃; for 10h; Inert atmosphere; Irradiation;

DOI:10.1021/acs.joc.9b03490

Reference yield:

benzylamine (100-46-9) → 1-benzyl-3,3-difluoro-4-((phenylselanyl)methyl)pyrrolidin-2-one (198547-54-5)

Guidance literature:

Multi-step reaction with 3 steps

1: ytterbium(III) triflate

2: potassium carbonate / Inert atmosphere; Reflux

3: dipotassium hydrogenphosphate / dimethyl sulfoxide / 10 h / 20 °C / Inert atmosphere; Irradiation

With dipotassium hydrogenphosphate; potassium carbonate; ytterbium(III) triflate; In dimethyl sulfoxide;

DOI:10.1021/acs.joc.9b03490

upstream raw materials:

diphenyl diselenide

N-allyl-N-benzyl-2-bromo-2,2-difluoroacetamide

benzylamine