198547-63-6Relevant academic research and scientific papers
Photocatalytic Cyclization/Defluorination Domino Sequence to Access 3-Fluoro-1,5-dihydro-2 H-pyrrol-2-one Scaffold
Ye, Zhi-Peng,Hu, Yuan-Zhuo,Guan, Jian-Ping,Chen, Kai,Liu, Fang,Gao, Jie,Xiao, Jun-An,Xiang, Hao-Yue,Chen, Xiao-Qing,Yang, Hua
, p. 4754 - 4758 (2021)
We herein report an unprecedented photoinduced cyclization/defluorination domino process of N-allylbromodifluoroacetamide with cyclic secondary amines. Consequently, a wide array of valuable 3-fluoro-1,5-dihydro-2H-pyrrol-2-ones were facilely prepared from readily available starting materials under mild conditions. Preliminary mechanistic investigations suggest that a radical chain propagation and amine-promoted defluorination pathway are presumably involved in this transformation.
Visible Light-Promoted Radical Relay Cyclization/C-C Bond Formation of N-Allylbromodifluoroacetamides with Quinoxalin-2(1 H)-ones
Ye, Zhi-Peng,Liu, Fang,Duan, Xin-Yu,Gao, Jie,Guan, Jian-Ping,Xiao, Jun-An,Xiang, Hao-Yue,Chen, Kai,Yang, Hua
, p. 17173 - 17183 (2021/11/18)
A visible light-promoted radical relay of N-allylbromodifluoroacetamide with quinoxalin-2(1H)-ones was developed in which 5-exo-trig cyclization and C-C bond formation were involved. This protocol was performed under mild conditions to facilely offer a variety of hybrid molecules bearing both quinoxalin-2(1H)-one and 3,3-difluoro-γ-lactam motifs. These prepared novel skeletons would expand the accessible chemical space for structurally complex heterocycles with potential biological activities.
Visible-Light-Induced, Catalyst-Free Radical Cross-Coupling Cyclization of N-Allylbromodifluoroacetamides with Disulfides or Diselenides
Chen, Xiao-Qing,Hu, Yuan-Zhuo,Huang, Ping,Liu, Fang,Song, Dan,Xia, Peng-Ju,Xiang, Hao-Yue,Xiao, Jun-An,Yang, Hua,Ye, Zhi-Peng
, p. 5670 - 5682 (2020/05/18)
A visible-light-induced, catalyst-free radical cross-coupling cyclization of diselenides or disulfides with N-allylbromodifluoroacetamide has been developed. This developed protocol exhibits good functional group tolerance and affords a variety of 4-thio-
Construction of Boronated γ-Lactams via Palladium-Catalyzed Intramolecular Boryldifluoroalkylation of Alkenes
Lin, Wu-Jie,Liu, Xue-Yuan,Wang, Jin-Lin,Wang, Yu-Zhao,Zhao, Yi-Chuan,Zou, Jian-Yu
supporting information, p. 5009 - 5013 (2020/10/06)
An approach for the preparation of boronated γ-lactams via palladium-catalyzed boryldifluoroalkylation of alkenes with α-bromodifluoroacetamides was developed. This method exhibits good functional group tolerance. Various boronated products were obtained in moderate to good yields for 1 h. Mechanistic studies indicated that this reaction may involve an intramolecular radical cascade cyclization process. (Figure presented.).
