1-HYDROXYURACIL

Base Information

• Chemical Name: 1-HYDROXYURACIL
• CAS No.: 6584-65-2
• Molecular Formula: C₄H₄N₂O₃
• Molecular Weight: 128.087
• Mol file: 6584-65-2.mol

Synonyms:N-hydroxyuracil;1-hydroxy-1H-pyrimidine-2,4-dione;1-Hydroxy-uracil;1-Hydroxyuracil;

Chemical Property of 1-HYDROXYURACIL

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 75.09000
• Density: 1.667g/cm³
• LogP: -1.22610

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-HYDROXYURACIL

There total 2 articles about 1-HYDROXYURACIL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(benzyloxy)uracil (721-01-7) → N-1-Hydroxyuracyl (6584-65-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; cyclohexane; at 60 ℃; for 5h;

DOI:10.1039/b006600l

Reference yield:

→ N-1-Hydroxyuracyl (6584-65-2)

Guidance literature:

1-Benzyloxy-uracil, 27percent HBr/Eg./Δ/Dampfbad;

DOI:10.1007/BF00901733

Reference yield: 23.0%

N-1-Hydroxyuracyl (6584-65-2) + [(S)-3-Hydroxy-2-(4-methoxy-benzyloxycarbonylamino)-propionylamino]-acetic acid ethyl ester → [(S)-3-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yloxy)-2-(4-methoxy-benzyloxycarbonylamino)-propionylamino]-acetic acid ethyl ester

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In N,N-dimethyl-formamide; for 15h;

DOI:10.1080/07328319608002398

upstream raw materials:

1-(benzyloxy)uracil

Downstream raw materials:

1-(2,3,5-Tri-O-benzoyl-β-D-ribofuranosyloxy)uracil

N-(2,3,5-tri-O-benzoyl-α-D-ribofuranosyl)uracil

1-((2S,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yloxy)-1H-pyrimidine-2,4-dione

1-((2R,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yloxy)-1H-pyrimidine-2,4-dione

Refernces