2,4(1H,3H)-Pyrimidinedione, 1-(phenylmethoxy)-

Base Information

• Chemical Name: 2,4(1H,3H)-Pyrimidinedione, 1-(phenylmethoxy)-
• CAS No.: 721-01-7
• Molecular Formula: C11H10N2O3
• Molecular Weight: 218.212

Synonyms:

Chemical Property of 2,4(1H,3H)-Pyrimidinedione, 1-(phenylmethoxy)-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4(1H,3H)-Pyrimidinedione, 1-(phenylmethoxy)-

There total 6 articles about 2,4(1H,3H)-Pyrimidinedione, 1-(phenylmethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

methyl 3,3-dimethoxypropionate (7424-91-1) + benzyloxyurea (2048-50-2) → 1-(benzyloxy)uracil (721-01-7)

Guidance literature:

With sodium; In ethanol; 1.) 20 deg C, 3 h, 2.) reflux, 17 h, 3.) 10 deg C, 4 h;

DOI:10.1021/jo961901m

Reference yield:

ethyl 3,3-diethoxy-2-methylpropionate (36056-90-3) + benzyloxyurea (2048-50-2) → 1-(benzyloxy)uracil (721-01-7)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; mineral oil; at 65 ℃; for 24h; Inert atmosphere;

Reference yield:

benzyloxyurea (2048-50-2) + 3,3-dimethoxypropionic acid ethyl ester (262293-82-3) → 1-(benzyloxy)uracil (721-01-7)

Guidance literature:

benzyloxyurea; In dimethyl sulfoxide; at 70 ℃; for 22h;

3,3-dimethoxypropionic acid ethyl ester; With sodium; In ethanol;

DOI:10.1039/b006600l

upstream raw materials:

methyl 3,3-dimethoxypropionate

benzyloxyurea

3,3-dimethoxypropionic acid ethyl ester

N-benzyloxyamine

Downstream raw materials:

3-Benzyloxyimino-2,2-dichlor-propionsaeureamid

N-1-Hydroxyuracyl

1-hydroxy-3-benzylpyrimidin-2,4-dione

tris(2-(6-{1-[1-(benzyloxy)-2-oxo-1,2-dihydropyrimidin-4-yl]amino}octanamido)ethyl)amine

Refernces

10.1007/BF00901242

The research aims to synthesize various 5-halogenated derivatives, particularly 5-fluorinated compounds, of N-benzyloxy and N-hydroxyuracils. The study explores the halogenation of these uracil derivatives and investigates the feasibility of converting 5-halogenated compounds to 5-fluorinated ones through different chemical methods. 1-benzyloxyuracil is a key starting material used for the synthesis of various 5-halogenated derivatives, particularly 5-fluorinated compounds. It is described as a compound that reacts with different halogens (such as chlorine, bromine, and iodine) under specific conditions to form various halogenated products. The study concludes that while the synthesis of 5-fluorinated uracil derivatives is possible through specific routes, direct halogen substitution is challenging, and alternative synthetic strategies are necessary to achieve the desired 5-fluorinated compounds.

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