6-(5-((2-(methylsulfonamido)ethylamino)methyl)furan-2-yl)-N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)quinazolin-4-amine

Base Information

Chemical Name:6-(5-((2-(methylsulfonamido)ethylamino)methyl)furan-2-yl)-N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)quinazolin-4-amine
CAS No.:1275595-88-4
Molecular Formula:C₂₉H₂₇ClFN₅O₄S
Molecular Weight:596.082
Hs Code.:

Synonyms:6-(5-((2-(methylsulfonamido)ethylamino)methyl)furan-2-yl)-N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)quinazolin-4-amine

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Chemical Property of 6-(5-((2-(methylsulfonamido)ethylamino)methyl)furan-2-yl)-N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)quinazolin-4-amine

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Technology Process of 6-(5-((2-(methylsulfonamido)ethylamino)methyl)furan-2-yl)-N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)quinazolin-4-amine

There total 4 articles about 6-(5-((2-(methylsulfonamido)ethylamino)methyl)furan-2-yl)-N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)quinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 202197-61-3
N-(2-aminoethyl)methanesulfonamide hydrochloride

: 231278-84-5
5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde

: 1275595-88-4
6-(5-((2-(methylsulfonamido)ethylamino)methyl)furan-2-yl)-N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)quinazolin-4-amine

Guidance literature:: N-(2-aminoethyl)methanesulfonamide hydrochloride; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde; With triethylamine; In methanol; dichloromethane; at 20 ℃;

With methanol; sodium tetrahydroborate; In dichloromethane; at 20 ℃; Cooling with ice;

Reference yield:

: C₂₉H₂₅ClFN₅O₄S

: 1275595-88-4
6-(5-((2-(methylsulfonamido)ethylamino)methyl)furan-2-yl)-N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)quinazolin-4-amine

Guidance literature:: With sodium triacetoxyborohydride; In ethanol; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.09.032

Reference yield:

: 231278-20-9
N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-amine

: 1275595-88-4
6-(5-((2-(methylsulfonamido)ethylamino)methyl)furan-2-yl)-N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / ethanol / 2.5 h / 20 °C / Inert atmosphere; Reflux

2: sodium triacetoxyborohydride / ethanol / 2 h / 20 °C / Inert atmosphere

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium triacetoxyborohydride; triethylamine; In ethanol;
DOI:10.1016/j.ejmech.2013.09.032