(2-iodo-4-methoxyphenyl)methanol

Base Information

• Chemical Name: (2-iodo-4-methoxyphenyl)methanol
• CAS No.: 1379329-63-1
• Molecular Formula: C₈H₉IO₂
• Molecular Weight: 264.063
• Mol file: 1379329-63-1.mol

Synonyms:(2-iodo-4-methoxyphenyl)methanol

Chemical Property of (2-iodo-4-methoxyphenyl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (2-iodo-4-methoxyphenyl)methanol

There total 3 articles about (2-iodo-4-methoxyphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-iodo-4-methoxybenzoic acid (54435-09-5) → (2-iodo-4-methoxyphenyl)methanol (1379329-63-1)

Guidance literature:

2-iodo-4-methoxybenzoic acid; With chloroformic acid ethyl ester; triethylamine; at 0 ℃; for 1h;

With sodium tetrahydroborate; In water; for 1.5h;

DOI:10.1039/c4ob00694a

Reference yield:

4-methoxyanthranilic acid (4294-95-5) → (2-iodo-4-methoxyphenyl)methanol (1379329-63-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuric acid; sodium nitrite / dimethyl sulfoxide / 1 h / 20 °C

1.2: 2 h

2.1: triethylamine; chloroformic acid ethyl ester / 1 h / 0 °C

2.2: 1.5 h

With sulfuric acid; chloroformic acid ethyl ester; triethylamine; sodium nitrite; In dimethyl sulfoxide;

DOI:10.1039/c4ob00694a

Reference yield:

4-Methoxybenzyl alcohol (105-13-5) → (2-iodo-4-methoxyphenyl)methanol (1379329-63-1)

Guidance literature:

With iodine; silver trifluoroacetate; In chloroform; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1039/c6ob02802k

upstream raw materials:

4-methoxyanthranilic acid

2-iodo-4-methoxybenzoic acid

4-Methoxybenzyl alcohol

Downstream raw materials:

(Z)-tert-butyl (2-(2-(hydroxymethyl)-5-methoxystyryl)phenyl)carbamate

tert-butyl (2-((2-(hydroxymethyl)-5-methoxyphenyl)ethynyl)phenyl)carbamate

(Z)-tert-butyl (2-(2-formyl-5-methoxystyryl)phenyl)carbamate

(2-((2-aminophenyl)ethynyl)-4-methoxyphenyl)methanol