ethyl 8-phenyl-1-thia-4-azaspiro[4.5]decane-3-carboxylate

Base Information

• Chemical Name: ethyl 8-phenyl-1-thia-4-azaspiro[4.5]decane-3-carboxylate
• CAS No.: 158745-64-3
• Molecular Formula: C₁₇H₂₃NO₂S
• Molecular Weight: 305.441
• Mol file: 158745-64-3.mol

Synonyms:8-Phenyl-1-thia-4-aza-spiro[4.5]decane-3-carboxylic acid ethyl ester

Chemical Property of ethyl 8-phenyl-1-thia-4-azaspiro[4.5]decane-3-carboxylate

Chemical Property:

• Boiling Point: 452.1±45.0 °C(Predicted)
• PKA: 7.12±0.60(Predicted)
• Density: 1.17±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Ethyl 8-phenyl-1-thia-4-azaspiro[4.5]decane-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 8-phenyl-1-thia-4-azaspiro[4.5]decane-3-carboxylate

There total 1 articles about ethyl 8-phenyl-1-thia-4-azaspiro[4.5]decane-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-phenyl-4-cyclohexanone (4894-75-1) + L-cysteine ethyl ester hydrochloride (868-59-7) → 8-Phenyl-1-thia-4-aza-spiro[4.5]decane-3-carboxylic acid ethyl ester (158745-64-3)

Guidance literature:

In ethanol; at 70 ℃; for 0.5h;

DOI:10.1002/jhet.5570340607

Reference yield: 59.0%

chloroacetyl chloride (79-04-9) + 8-Phenyl-1-thia-4-aza-spiro[4.5]decane-3-carboxylic acid ethyl ester (158745-64-3) → 4-(2-Chloro-acetyl)-8-phenyl-1-thia-4-aza-spiro[4.5]decane-3-carboxylic acid ethyl ester

Guidance literature:

With sodium carbonate; In dichloromethane; for 24h; Ambient temperature;

DOI:10.1002/jhet.5570340607

Reference yield:

8-Phenyl-1-thia-4-aza-spiro[4.5]decane-3-carboxylic acid ethyl ester (158745-64-3) → 8-Phenyl-4-(2-pyrrolidin-1-yl-acetyl)-1-thia-4-aza-spiro[4.5]decane-3-carboxylic acid ethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / sodium carbonate / CH₂Cl₂ / 24 h / Ambient temperature

2: 62 percent / Na₂CO₃ / methanol / 20 h / Heating

With sodium carbonate; In methanol; dichloromethane;

DOI:10.1002/jhet.5570340607

upstream raw materials:

1-phenyl-4-cyclohexanone

L-cysteine ethyl ester hydrochloride

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 158745-64-3 ethyl 8-phenyl-1-thia-4-azaspiro[4.5]decane-3-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send