Z-L-Ala N-methylcarbamoylmethyl ester

Base Information

• Chemical Name: Z-L-Ala N-methylcarbamoylmethyl ester
• CAS No.: 203640-48-6
• Molecular Formula: C₁₄H₁₈N₂O₅
• Molecular Weight: 294.307
• Mol file: 203640-48-6.mol

Synonyms:Z-L-Ala N-methylcarbamoylmethyl ester

Chemical Property of Z-L-Ala N-methylcarbamoylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of Z-L-Ala N-methylcarbamoylmethyl ester

There total 1 articles about Z-L-Ala N-methylcarbamoylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloroacetylmethylamide (96-30-0) + N-Cbz-Ala (1142-20-7) → Z-L-Ala N-methylcarbamoylmethyl ester (203640-48-6)

Guidance literature:

N-Cbz-Ala; With caesium carbonate; In methanol;

chloroacetylmethylamide; In N,N-dimethyl-formamide; at 60 ℃;

DOI:10.1039/b004180g

Reference yield: 89.1%

(2S)-amino-4-methylpentanamide hydrochloride (10466-61-2) + Z-L-Ala N-methylcarbamoylmethyl ester (203640-48-6) → N-Cbz-Ala (1142-20-7) + Z-(S)-Ala-(S)-Leu-NH2 (18323-56-3)

Guidance literature:

With α-chymotripsin on Celite; Tris buffer; TEA; In acetonitrile; at 30 ℃; for 48h; Yields of byproduct given;

DOI:10.1016/S0040-4039(97)10798-5

Reference yield: 89.1%

(2S)-amino-4-methylpentanamide hydrochloride (10466-61-2) + Z-L-Ala N-methylcarbamoylmethyl ester (203640-48-6) → Z-(S)-Ala-(S)-Leu-NH2 (18323-56-3)

Guidance literature:

With α-chymotrypsin immobilised on Celite; Tris buffer; triethylamine; In acetonitrile; at 30 ℃; for 48h; pH=7.8;

DOI:10.1039/b004180g

upstream raw materials:

chloroacetylmethylamide

N-Cbz-Ala

Downstream raw materials:

N-Cbz-Ala

Z-(S)-Ala-(S)-Leu-NH₂