(S)-2-(methoxymethoxy)-3-methylbutanal

Base Information

• Chemical Name: (S)-2-(methoxymethoxy)-3-methylbutanal
• CAS No.: 177469-73-7
• Molecular Formula: C₇H₁₄O₃
• Molecular Weight: 146.186
• Mol file: 177469-73-7.mol

Synonyms:(S)-2-(methoxymethoxy)-3-methylbutanal

Chemical Property of (S)-2-(methoxymethoxy)-3-methylbutanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(methoxymethoxy)-3-methylbutanal

There total 1 articles about (S)-2-(methoxymethoxy)-3-methylbutanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,2,2-Trichloro-N-((E)-(1R,4S)-4-methoxymethoxy-1,5-dimethyl-1-phenyl-hex-2-enyl)-acetamide → (S)-2-(methoxymethoxy)-3-methylbutanal (177469-73-7) + 2,2,2-Trichloro-N-((S)-1-methyl-2-oxo-1-phenyl-ethyl)-acetamide (177273-82-4)

Guidance literature:

With dimethylsulfide; ozone; for 12h;

DOI:10.1016/0040-4039(96)00393-0

Reference yield:

(S)-2-(methoxymethoxy)-3-methylbutanal (177469-73-7) → tacalcitol (57333-96-7)

Guidance literature:

Multi-step reaction with 7 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 15 h / -78 - 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 17 h / 65 °C

3: hydrogen; palladium 10% on activated carbon / methanol / 15 h

4: dipyridinium dichromate / dichloromethane / 20 °C

5: n-butyllithium / tetrahydrofuran / 18 h / -78 °C

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Darkness

7: hydrogen fluoride / acetonitrile; water / 24 h / 20 °C

With dipyridinium dichromate; n-butyllithium; palladium 10% on activated carbon; hydrogen fluoride; tetrabutyl ammonium fluoride; hydrogen; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;

DOI:10.1016/j.tetlet.2017.07.103

Reference yield:

(S)-2-(methoxymethoxy)-3-methylbutanal (177469-73-7) → 1α-[(tert-butyldimethylsilyl)oxy]-24R-[(methoxymethyl)oxy]-vitamin D3 tert-butyldimethylsilyl ether (188949-02-2)

Guidance literature:

Multi-step reaction with 5 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 15 h / -78 - 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 17 h / 65 °C

3: hydrogen; palladium 10% on activated carbon / methanol / 15 h

4: dipyridinium dichromate / dichloromethane / 20 °C

5: n-butyllithium / tetrahydrofuran / 18 h / -78 °C

With dipyridinium dichromate; n-butyllithium; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/j.tetlet.2017.07.103

Downstream raw materials:

tacalcitol

1α-[(tert-butyldimethylsilyl)oxy]-24R-[(methoxymethyl)oxy]-vitamin D₃ tert-butyldimethylsilyl ether