2,2,2-Trichloro-N-((S)-1-methyl-2-oxo-1-phenyl-ethyl)-acetamide

Base Information

• Chemical Name: 2,2,2-Trichloro-N-((S)-1-methyl-2-oxo-1-phenyl-ethyl)-acetamide
• CAS No.: 177273-82-4
• Molecular Formula: C₁₁H₁₀Cl₃NO₂
• Molecular Weight: 294.565
• Mol file: 177273-82-4.mol

Synonyms:2,2,2-Trichloro-N-((S)-1-methyl-2-oxo-1-phenyl-ethyl)-acetamide

Chemical Property of 2,2,2-Trichloro-N-((S)-1-methyl-2-oxo-1-phenyl-ethyl)-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,2-Trichloro-N-((S)-1-methyl-2-oxo-1-phenyl-ethyl)-acetamide

There total 3 articles about 2,2,2-Trichloro-N-((S)-1-methyl-2-oxo-1-phenyl-ethyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,2,2-Trichloro-N-((E)-(1R,4S)-4-methoxymethoxy-1,5-dimethyl-1-phenyl-hex-2-enyl)-acetamide → (S)-2-(methoxymethoxy)-3-methylbutanal (177469-73-7) + 2,2,2-Trichloro-N-((S)-1-methyl-2-oxo-1-phenyl-ethyl)-acetamide (177273-82-4)

Guidance literature:

With dimethylsulfide; ozone; for 12h;

DOI:10.1016/0040-4039(96)00393-0

Reference yield:

2,2,2-Trichloro-acetimidic acid (E)-(S)-1-((S)-1-methoxymethoxy-2-methyl-propyl)-3-phenyl-but-2-enyl ester → 2,2,2-Trichloro-N-((S)-1-methyl-2-oxo-1-phenyl-ethyl)-acetamide (177273-82-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / xylene / 4 h / 140 °C

2: 98 percent / O₃, Me₂S / 12 h

With dimethylsulfide; ozone; In xylene;

DOI:10.1016/0040-4039(96)00393-0

Reference yield:

(E)-(4S,5S)-5-Methoxymethoxy-6-methyl-2-phenyl-hept-2-en-4-ol → 2,2,2-Trichloro-N-((S)-1-methyl-2-oxo-1-phenyl-ethyl)-acetamide (177273-82-4)

Guidance literature:

Multi-step reaction with 3 steps

1: DBU / CH₂Cl₂ / 1 h / -78 °C

2: 70 percent / xylene / 4 h / 140 °C

3: 98 percent / O₃, Me₂S / 12 h

With dimethylsulfide; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; xylene;

DOI:10.1016/0040-4039(96)00393-0

Downstream raw materials:

(S)-2-Phenyl-2-(2,2,2-trichloro-acetylamino)-propionic acid

(S)-2-methyl-2-phenylglycine